{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:15:39Z","timestamp":1783487739829,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Paragangliomas of the urinary bladder (UBPGLs) are rare neuroendocrine tumours and pose a diagnostic and surgical challenge. It remains unclear what factors contribute to a timely presurgical diagnosis. The purpose of this study is to identify factors contributing to missing the diagnosis of UBPGLs before surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>A total of 73 patients from 11 centres in China, and 51 patients from 6 centres in Europe and 1 center in the United States were included. Clinical, surgical and genetic data were collected and compared in patients diagnosed before versus after surgery. Logistic regression analysis was used to identify clinical factors associated with initiation of presurgical biochemical testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all patients, only 47.6% were diagnosed before surgery. These patients were younger (34.0 vs. 54.0 years, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), had larger tumours (2.9 vs. 1.8\u2009cm, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and more had a <jats:italic>SDHB<\/jats:italic> pathogenic variant (54.7% vs. 11.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) than those diagnosed after surgery. Patients with presurgical diagnosis presented with more micturition spells (39.7% vs. 15.9%, <jats:italic>p<\/jats:italic>\u2009=\u2009.003), hypertension (50.0% vs. 31.7%, <jats:italic>p<\/jats:italic>\u2009=\u2009.041) and catecholamine\u2010related symptoms (37.9% vs. 17.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.012). Multivariable logistic analysis revealed that presence of younger age (&lt;35 years, odds ratio [OR]\u2009=\u20096.47, <jats:italic>p<\/jats:italic>\u2009=\u2009.013), micturition spells (OR\u2009=\u20096.79, <jats:italic>p<\/jats:italic>\u2009=\u2009.007), hypertension (OR\u2009=\u20093.98, <jats:italic>p<\/jats:italic>\u2009=\u2009.011), and sweating (OR\u2009=\u200941.72, <jats:italic>p<\/jats:italic>\u2009=\u2009.013) increased the probability of initiating presurgical biochemical testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most patients with UBPGL are diagnosed after surgery. Young age, hypertension, micturition spells and sweating are clues in assisting to initiate early biochemical testing and thus may establish a timely presurgical diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15058","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:04:09Z","timestamp":1712912649000},"page":"234-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnosis and management of urinary bladder paragangliomas: A Sino\u2010American\u2010European retrospective observational study"],"prefix":"10.1111","volume":"101","author":[{"given":"Yingxian","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Urology, Xiangya Hospital Central South University Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pamporaki","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"Department of Medicine III, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangya Hospital Central South University Changsha China"},{"name":"Department of Medicine III, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bechmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"Department of Medicine III, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Meuter","sequence":"additional","affiliation":[{"name":"Section of Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbao","family":"Wei","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University and Department of Urology Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Huang","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University and Department of Urology Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University and Department of Urology Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunbin","family":"Yu","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University and Department of Urology Fujian Provincial Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Robledo","sequence":"additional","affiliation":[{"name":"Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel J.","family":"Soria","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology European University of Madrid, University Getafe Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Urology Longyan First Affiliated Hospital of Fujian Medical University Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology Longyan First Affiliated Hospital of Fujian Medical University Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri J. 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