{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:46:28Z","timestamp":1770615988017,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Skin changes in acromegaly are often the first sign of the disease. The aim of this study was to describe the cutaneous findings in patients with acromegaly. In addition, a secondary aim was to investigate the possible association of these findings with remission status and concomitant endocrinopathies.<\/jats:p><\/jats:sec>Design, Patients, and Measurements<\/jats:title>In this prospective multicenter study, 278 patients over the age of 18 years with acromegaly who were followed up in 14 different tertiary healthcare institutions were included. These patients, who were followed up by the Endocrinology Department, were then referred to a dermatologist for dermatological examination. The frequency of skin lesions was investigated by detailed dermatologic examination. Dermatological diagnosis is reached by clinical, dermatological and\/or dermoscopic examination, and rarely skin punch biopsy examinations in suspicious cases. The possible association of the skin findings between remitted and nonremitted patients and with concomitant endocrinopathies were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>The most common skin findings in patients with acromegaly in our study were skin tags (52.5%), cherry angiomas (47.4%), seborrhoea (37%), varicose veins (33%), acneiform lesions (28.8%), hyperhidrosis (26.9%) and hypertrichosis (18.3%). Hypertrichosis was significantly more prevalent in patients nonremitted (p<\/jats:italic>: .001), while xerosis cutis was significantly more prevalent in patients remitted (p<\/jats:italic>: .001). The frequency of diabetes mellitus and hypothyroidism was significantly higher in patients with varicose veins and seborrhoeic keratosis than those without. Additionally, the coexistence of hypothyroidism, hyperthyroidism\u00a0and galactorrhea was significantly higher in patients with Cherry angioma than in those without Cherry angioma (p<\/jats:italic>\u2010values: .024, .034\u00a0and .027, respectively). The frequency of hypogonadism in those with xerosis cutis was significantly higher than in those without (p<\/jats:italic>: .035).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cutaneous androgenization findings such as skin tag, seborrhoea, acne\u00a0and acanthosis nigricans are common in patients with acromegaly. Clinicians should be aware that skin findings associated with insulin resistance may develop in these patients. It can be said that the remission state in acromegaly has no curative effect on cutaneous findings. Only patients in remission were less likely to have hypertrichosis. This may allow earlier review of the follow\u2010up and treatment of acromegaly patients presenting with complaints of hypertrichosis. Additionally, it can be said that patients with skin findings such as cherry angioma may be predisposed to a second endocrinopathy, especially hypothyroidism. Including dermatology in a multidisciplinary perspective in acromegaly patient management would be beneficial to detect cutaneous findings earlier.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15071","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T12:54:39Z","timestamp":1715086479000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cutaneous findings in patients with acromegaly and its relationship with concomitant endocrinopathies"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-4551","authenticated-orcid":false,"given":"\u0130sa","family":"An","sequence":"first","affiliation":[{"name":"Department of Dermatology \u015eanl\u0131urfa Training and Research Hospital Sanl\u0131urfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz Cebeci","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Dermatology G\u00f6ztepe Prof. Dr. S\u00fcleyman Yal\u00e7\u0131n City Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asl\u0131","family":"Bilgi\u00e7","sequence":"additional","affiliation":[{"name":"Department of Dermatology Akdeniz University Medical Faculty Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun \u015eikar","family":"Akt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kocaeli University Medical Faculty Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nam\u0131k Kemal University Medical Faculty Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demet","family":"Kartal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erciyes University Medical Faculty Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salih Levent","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erciyes University Medical Faculty Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezgi Sar\u0131kaya","family":"Solak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Trakya University Medical Faculty Edirne Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Adnan Menderes University Medical Faculty Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Erdi","family":"\u015eanl\u0131","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara University Medical Faculty Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130ncilay Kalay","family":"Y\u0131ld\u0131zhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara University Medical Faculty Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Turhan","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Celal Bayar University Medical Faculty Manisa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lkin","family":"Zindanci","sequence":"additional","affiliation":[{"name":"Department of Dermatology Umraniye Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevil","family":"Sava\u015f","sequence":"additional","affiliation":[{"name":"Department of Dermatology \u0130stanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gazi Ya\u015fargil Training and Research Hospital Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Cinel","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Mehmet Akif Inan Education and Research Hospital \u015eanl\u0131urfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Nazl\u0131 Serin","family":"Ata\u015f","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Akdeniz University Medical Faculty Antalya 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