{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:08:45Z","timestamp":1781719725694,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To report our experience with\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluoro\u2010ethyl\u2010tyrosine (FET) positron emission tomography\u2010computed tomography (PET\u2010CT) co\u2010registered with magnetic resonance imaging (MRI) (FET\u2010PET\/MRI\n                      <jats:sup>CR<\/jats:sup>\n                      ) in the care trajectory for persistent acromegaly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Ten patients with insufficiently controlled acromegaly referred to our team to evaluate surgical options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>FET\u2010PET\/MRICR was used to support decision\u2010making if MRI alone and multidisciplinary team evaluation did not provide sufficient clarity to proceed to surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FET\u2010PET\/MRI\n                      <jats:sup>CR<\/jats:sup>\n                      showed suspicious (para)sellar tracer uptake in all patients. In five patients FET\u2010PET\/MRI\n                      <jats:sup>CR<\/jats:sup>\n                      was fully concordant with conventional MRI, and in one patient partially concordant. FET\u2010PET\/MRI\n                      <jats:sup>CR<\/jats:sup>\n                      identified suggestive new foci in four other patients. Surgical re\u2010exploration was performed in nine patients (aimed at total resection (6), debulking (2), diagnosis (1)), and one patient underwent radiation therapy. In 7 of 9 (78%) operated patients FET\u2010PET\/MRI\n                      <jats:sup>CR<\/jats:sup>\n                      findings were confirmed intraoperatively, and in six (67%) also histologically. IGF\u20101 decreased significantly in eight patients (89%). All patients showed clinical improvement. Complete biochemical remission was achieved in three patients (50% of procedures in which total resection was anticipated feasible). Biochemistry improved in five and was unchanged in one patient. No permanent complications occurred. At six months, optimal outcome (preoperative intended goal achieved without permanent complications) was achieved in six (67%) patients and an intermediate outcome (goal not achieved, but no complications) in the other three patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In patients with persisting acromegaly without a clear surgical target on MRI, FET\u2010PET\/MRI\n                      <jats:sup>CR<\/jats:sup>\n                      is a new tracer to provide additional information to aid decision\u2010making by the multidisciplinary pituitary team.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.15079","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T04:51:28Z","timestamp":1717131088000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<sup>18<\/sup>\n                    F\u2010fluoro\u2010ethyl\u2010tyrosine PET co\u2010registered with MRI in patients with persisting acromegaly"],"prefix":"10.1111","volume":"101","author":[{"given":"Leontine E. H.","family":"Bakker","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden The Netherlands"},{"name":"Center for Endocrine Tumors Leiden (CETL), Pituitary Center, Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J. T.","family":"Verstegen","sequence":"additional","affiliation":[{"name":"Center for Endocrine Tumors Leiden (CETL), Pituitary Center, Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Neurosurgery Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra C.","family":"Manole","sequence":"additional","affiliation":[{"name":"Department of Neuroendocrinology National Institute of Endocrinology CI Parhon Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangling","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology Section of Nuclear Medicine, Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J. M.","family":"Decramer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris C. M.","family":"Pelsma","sequence":"additional","affiliation":[{"name":"Department of Quality and Patient Safety Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Kruit","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit M.","family":"Verbist","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annenienke","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5745-6832","authenticated-orcid":false,"given":"Mark","family":"Gurnell","sequence":"additional","affiliation":[{"name":"Wellcome\u2013MRC Institute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge Biomedical Campus Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idris","family":"Ghariq","sequence":"additional","affiliation":[{"name":"Department of Radiology Section of Nuclear Medicine, Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter R.","family":"van Furth","sequence":"additional","affiliation":[{"name":"Center for Endocrine Tumors Leiden (CETL), Pituitary Center, Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Neurosurgery Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke R.","family":"Biermasz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden The Netherlands"},{"name":"Center for Endocrine Tumors Leiden (CETL), Pituitary Center, Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka M.","family":"Pereira Arias\u2010Bouda","sequence":"additional","affiliation":[{"name":"Department of Radiology Section of Nuclear Medicine, Leiden University Medical Center Leiden The 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