{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:24:10Z","timestamp":1791167050713,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Diabetic nephropathy is a prevalent cause of chronic kidney disease worldwide. Magnesium plays a critical role in insulin resistance, and insulin, in turn, regulates magnesium levels. We aimed to investigate the association between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus (T2DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>This retrospective single\u2010centre study encompassed 1178 patients aged 18 and above with T2DM, who attended our outpatient clinic between January 2019 and August 2020. Albuminuria levels were categorised according to Kidney Disease Outcomes Quality Initiative guidelines. In the literature, when examining cut\u2010off values for hypomagnesemia, it is observed that studies typically use hospital normal level as a reference point. Hypomagnesemia, defined as magnesium levels below 1.6\u2009mg\/dL, was compared to normomagnesemia (magnesium between 1.6 and 2.4\u2009mg\/dL). The primary objective was to explore the impact of magnesium levels on albuminuria, while the secondary objective was to determine the prevalence of hypomagnesemia. The multivariate logistic regression analyses were performed according to age, gender (male), HbA1c, and presence of hypomagnesemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the participants was 58.7\u2009\u00b1\u200912.2 years, with 44% being male. Hypomagnesemia was identified in 5.3% of the patients. Advanced age and female gender were more common among patients with hypomagnesemia (<jats:italic>p<\/jats:italic>\u2009=\u2009.001). Magnesium levels exhibited a negative correlation with HbA1c and fasting blood glucose, and a positive correlation with creatinine levels (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.117, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.131, <jats:italic>r<\/jats:italic>\u2009=\u2009.117, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for all three variables). Hypomagnesemia was significantly more prevalent in patients with albuminuria (15.9% vs. 4.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Moreover, participants with the presence of hypomagnesemia were independently associated with a higher risk of albuminuria (odds ratio 3,64 1.76\u20137.52, <jats:italic>p<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Albuminuria is more frequently observed in patients with hypomagnesemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15094","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T05:33:45Z","timestamp":1717565625000},"page":"216-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The relationship between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3324-5923","authenticated-orcid":false,"given":"Edibe S.","family":"Eker","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Haseki Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-2575","authenticated-orcid":false,"given":"Hayriye E.","family":"Atao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haseki Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-57"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30010-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw429"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2011.00434.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1260141"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S42054"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3933.ijam20170123"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"163","article-title":"Hypomagnesemia and mortality in patients with type 2 diabetes","volume":"21","author":"Curiel\u2010Garc\u00eda JA","year":"2008","journal-title":"Magnes 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Elem"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.103020"},{"issue":"2","key":"e_1_2_10_18_1","article-title":"Hypomagnesemia and its implications in type 2 diabetes mellitus\u2014a review article","volume":"4","author":"Chhabra S","year":"2013","journal-title":"WebmedCentral Diabetes"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013582"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"307","article-title":"Type 2 diabetes control and complications and their relation to serum magnesium level","volume":"18","author":"Alswat K","year":"2022","journal-title":"Arch\u00a0Med\u00a0Sci"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.1.134"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.15094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T13:11:09Z","timestamp":1723122669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.15094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/cen.15094"],"URL":"https:\/\/doi.org\/10.1111\/cen.15094","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2023-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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