{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:27:56Z","timestamp":1789421276330,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Compare the efficacy and safety of daily versus fortnightly oral vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      in treating symptomatic vitamin D deficiency in children aged 1\u221210 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Open labelled randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      Eighty children with symptomatic vitamin D deficiency were randomized into group daily (D) and group bolus (B) [40 in each group] to receive oral vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      , 4000 IU daily or 60,000 IU fortnightly for 12 weeks respectively. Both groups received daily oral calcium of 500\u2009mg\/day.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Serum calcium (Ca), phosphate (P), alkaline phosphatase (ALP), 25\u2010hydroxy cholecalciferol (25(OH)D), parathyroid hormone (PTH) levels, urine calcium: creatinine ratio and radiological score were assessed at baseline, 4 weeks and 12 weeks. At the end of 12 weeks, 74 children were available for evaluation of the efficacy and safety of both regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both regimens led to a significant increase in Ca and P levels and a fall in ALP and PTH levels from baseline to 4 and 12 weeks of therapy, with no intergroup difference. At 4\u2010 and 12\u2010week assessments, all children in both treatment arms achieved 25(OH)D level in sufficiency range,\u00a0with no significant difference in their geometric mean.<\/jats:p>\n                    <jats:p>\n                      Both regimens were associated with asymptomatic transient hypercalcemia [group D\u201451.4% vs. group B\u201434.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u22120.14] and hypercalciuria (5.7%) in group D that resolved spontaneously on follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Daily and fortnightly oral vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      in similar cumulative doses are efficacious for treating symptomatic vitamin D deficiency in children (1\u221210 years). Treated children should be monitored for serum 25(OH)D, Ca and urinary calcium creatinine ratio.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.15124","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T01:49:36Z","timestamp":1723600176000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Daily versus fortnightly oral vitamin D\n                    <sub>3<\/sub>\n                    in treatment of symptomatic vitamin D deficiency in children aged 1\u221210 years: An open labelled randomized controlled trial"],"prefix":"10.1111","volume":"101","author":[{"given":"Kumar Arghya Prasanna","family":"Mondal","sequence":"first","affiliation":[{"name":"Department of Pediatrics Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Kumar","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Delhi Cancer Registry BR Ambedkar IRCH, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-8835","authenticated-orcid":false,"given":"Anju","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0558-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21279-0"},{"issue":"3","key":"e_1_2_6_4_1","first-page":"167","article-title":"Vitamin D deficiency in children: an update on its prevalence, therapeutics and knowledge gaps","volume":"4","author":"Surve S","year":"2017","journal-title":"Indian J Nutri"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443136"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-022-2448-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12781"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2011-0368"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14497"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1168115"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2023-0146"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2653"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030348"},{"key":"e_1_2_6_15_1","volume-title":"Sample Size Calculations in Clinical Research","author":"Chow SC","year":"2008"},{"key":"e_1_2_6_16_1","first-page":"1131","article-title":"Kuppuswamy's socioeconomic status scale\u2010updating for 2007","volume":"74","author":"Kumar N","year":"2007","journal-title":"Indian J Pediatr"},{"key":"e_1_2_6_17_1","unstructured":"World Health Organization. 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