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Women with CAH experience menstrual irregularities due to androgen and glucocorticoid precursor interference with endometrial development and ovulation. Genital surgeries for virilization and urogenital anomalies further impact fertility and sexual function, leading to reduced heterosexual relationships among affected women. Fertility rates vary, with a lower prevalence of motherhood, primarily among those with classic CAH, necessitating optimized hormonal therapy for conception. Monitoring optimal disease control during pregnancy poses challenges due to hormonal fluctuations. Men with CAH often experience hypogonadotrophic hypogonadism and complications like testicular adrenal rest tissue, impacting fertility. Regular monitoring and intensified glucocorticoid therapy may restore spermatogenesis. Genetic counselling is vital to comprehend transmission risks and prenatal implications. Prenatal dexamethasone treatment in affected female fetuses prevents virilization but raises ethical and safety concerns, necessitating careful consideration and further research. The international \u201cPREDICT\u201d study aims to establish safer and more effective prenatal therapy in CAH, evaluating dosage, safety, and long\u2010term effects.<\/jats:p>","DOI":"10.1111\/cen.15131","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:46:01Z","timestamp":1728557161000},"page":"359-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prenatal and Pregnancy Management of Congenital Adrenal Hyperplasia"],"prefix":"10.1111","volume":"101","author":[{"given":"Hanna Franziska","family":"Nowotny","sequence":"first","affiliation":[{"name":"Department of Medicine IV LMU University Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Tschaidse","sequence":"additional","affiliation":[{"name":"Department of Medicine IV LMU University Hospital, LMU Munich Munich 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