{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:44:40Z","timestamp":1787719480004,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Adipose tissue has an important endocrine function by secreting a variety of hormones known as adipokines, such as Visfatin, Omentin\u20101 and Chemerin. On the other hand, these hormones are also secreted from places other than fatty tissues in the girl's genital system. The goal of this study was to demonstrate the secretory status of adipokines in patients with central precocious puberty (CPP) and their utility in the diagnosis of precocious puberty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 105 patients were included in the study (53 in the CPP group and 52 in the control group). The following were used as the CPP diagnostic criteria; breast development, basal LH measurement higher than 0.3\u2009IU\/L, peak LH level \u2265\u20095\u2009IU\/L, peak LH\/FSH ratio \u2265\u20090.66 (after 0.1\u2009mg GnRH stimulation test) and a difference of at least 1 year between bone and chronological age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference was detected between the groups in serum Omentin\u20101 and Chemerin levels, and no significant differences were detected between the groups in Visfatin values. The cut\u2010off values for the diagnosis of CPP were calculated as \u2264\u200948.9 with 81% sensitivity and 54% specificity for Omentin\u20101, and as \u2265\u2009417 with 85% sensitivity and 60% specificity for Chemerin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, we found that Omentin\u20101 level decreased and Chemerin level increased in lean girls with CPP. More studies are needed to elucidate how adipokines play roles in explaining the onset of CPP, and whether they may be used as a reliable marker for the diagnosis of CPP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15132","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:45:31Z","timestamp":1726472731000},"page":"413-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Serum Adipokine Levels in Girls With Central Precocious Puberty"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-7281","authenticated-orcid":false,"given":"Ilkin Seda Can","family":"Caglayan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-6807","authenticated-orcid":false,"given":"Nurullah","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-8782","authenticated-orcid":false,"given":"Serkan","family":"Bolat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Sivas Cumhuriyet University School of Medicine Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.058"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.08.003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046184"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05483"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803719"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1649"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118770547"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1176"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070196"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/232454"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.021"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1958947"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.032"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00572.2004"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161112999140217095038"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1506"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-27"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2023.04.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des089"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1102"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.2183"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02206.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-197007000-00018"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195909000-00030"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-5-1251"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501336"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2015-0034"},{"issue":"2","key":"e_1_2_12_30_1","first-page":"108","article-title":"Study of Omentin1 and Other Adipokines and Hormones in PCOS Patients","volume":"24","author":"Mahde A.","year":"2009","journal-title":"Oman Medical Journal"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat002"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17207575"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23391"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2809"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.15132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T10:58:24Z","timestamp":1741604304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.15132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/cen.15132"],"URL":"https:\/\/doi.org\/10.1111\/cen.15132","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"2024-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}