{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:17:44Z","timestamp":1771222664898,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We conducted a prospective randomized clinical trial to compare the efficacy of low\u2010 and high\u2010dose radioiodine for remnant ablation in patients with low\u2010risk differentiated thyroid cancer (DTC) in China. The first\u2010stage results showed equivalence was observed between the two groups. Here, we report recurrence and survival at 3\u20135 and 6\u201310 years and biochemical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Between January 2013 and December 2014, adult patients with DTC were enroled. Patients had undergone total or near\u2010total thyroidectomy, with or without cervical lymph node dissection, with tumour stages T1\u2013T3 with or without lymph node metastasis, but without distant metastasis. Patients were randomly assigned to the low\u2010dose (1850\u2009MBq) or high\u2010dose (3700\u2009MBq) radioiodine group. They were then followed up for 3\u20135 and 6\u201310 years. Data on biochemical abnormalities, recurrence and survival were analysed using Kolmogorov\u2013Smirnov and\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The data of 228 patients (mean age\u2009=\u200942 years; 70.6% women) were analysed, with 117 patients in the low\u2010dose group and 111 in the high\u2010dose group. There were no significant differences in biochemical abnormalities, recurrence, or survival rates at the 6\u201310\u2010year follow\u2010up (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05). Nine patients experienced recurrence in the low\u2010dose group (8.7%), while eight patients experienced recurrence in the high\u2010dose group (8.2%). The survival rates were 100% and 98.2% in the low\u2010 and high\u2010dose groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The long\u2010term effectiveness and safety of low\u2010dose (1850\u2009MBq) radioiodine are the same as those of high\u2010dose (3700\u2009MBq) radioiodine for thyroid remnant ablation in Chinese patients with low\u2010risk DTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.15134","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T01:44:18Z","timestamp":1725500658000},"page":"682-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Outcome of Low\u2010 and High\u2010Dose Radioiodine for Thyroid Remnant Ablation"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1337-3315","authenticated-orcid":false,"given":"Shiqi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-1095","authenticated-orcid":false,"given":"Fang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Shanghai Fourth Peoples' Hospital Affiliated to Tongji University Shanghai 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