{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T18:43:01Z","timestamp":1747680181480,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A link between maternal thyroid function and the placental biomarkers, soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF), has been brought forward. This study aimed to describe their association in early pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Eight hundred and fifty\u2010eight pregnant women from the North Denmark Region, 2013, with blood samples drawn in early pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Thyroid\u2010stimulating hormone (TSH), free thyroxine (fT4), thyroid\u2010peroxidase antibodies (TPO\u2010Ab), thyroglobulin antibodies (Tg\u2010Ab) (ADVIA Centaur XPT, Siemens Healthineers), sFlt\u20101 and PlGF (Kryptor Compact, ThermoFisher Scientific) were measured. The association between maternal TSH and fT4 and percentile (pc) levels of sFlt\u20101 and PlGF (&lt;\u200925th pc, 25\u201375th pc, &gt;\u200975th pc) was evaluated using regression analysis and reported as adjusted beta coefficient (a\u03b2). The frequency of maternal thyroid autoantibodies (TPO\u2010Ab &gt;\u200960\u2009U\/mL or Tg\u2010Ab &gt;\u200933\u2009U\/mL) by pc levels of sFlt\u20101 and PlGF was compared using chi\u2010squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher levels (&gt;\u200975th pc) of sFlt\u20101 associated with lower TSH (a\u03b2 0.62, 95% CI: 0.51\u20130.76) and higher fT4 (a\u03b2 1.03, 95% CI: 1.01\u20131.05). Higher levels of PlGF associated with lower TSH (a\u03b2 0.82, 95% CI: 0.69\u20130.98), but not with levels of fT4 (a\u03b2 1.00, 95% CI: 0.97\u20131.02). No association with maternal thyroid autoantibodies was found (TPO\u2010Ab: sFlt\u20101: <jats:italic>p<\/jats:italic>\u2010value 0.5 and PlGF: <jats:italic>p<\/jats:italic>\u2010value 0.1; Tg\u2010Ab: sFlt\u20101: <jats:italic>p<\/jats:italic>\u2010value 0.7 and PlGF: <jats:italic>p<\/jats:italic>\u2010value 0.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large cohort of Danish pregnant women, higher levels of sFlt\u20101 and PlGF associated with maternal thyroid function in early pregnancy, while there was no association with maternal thyroid autoantibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15145","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T06:10:04Z","timestamp":1728281404000},"page":"306-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal Thyroid Function and Biochemical Markers of Placental Function in Early Pregnancy"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6031-0137","authenticated-orcid":false,"given":"Maja H.","family":"Lundgaard","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne M.","family":"Sinding","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne N.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanna M. 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