{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:01:07Z","timestamp":1787702467888,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aetiology of impairments in autonomic modulation of heart rate variability (HRV) in polycystic ovary syndrome (PCOS) remains unclear, as does the impact of aerobic physical training (APT) on controlling endocrine\u2010metabolic disorders and HRV. This is because these women often present excess body fat. Therefore, we assessed whether the dysregulation in autonomic modulation of HRV in women with PCOS is due to endocrine\u2010metabolic disorders and whether the combination of excess body fat with endocrine\u2010metabolic disorders amplifies cardiovascular autonomic deficits. We also investigated whether APT positively influences autonomic modulation of HRV in PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Non\u2010randomised clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Women with and without PCOS with different percentages of body fat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Participants were divided into four groups: women without PCOS with a body fat percentage between 22% and 29% (CONTROL group; 22%\u201329%); CONTROL (30%\u201337%) group; PCOS (22%\u201329%) group; and PCOS (30%\u201337%) group. Hemodynamic, metabolic, and hormonal characteristics and HRV parameters were obtained before and after 16 weeks of APT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PCOS (22%\u201329%) group exhibited lower vagal modulation than the CONTROL (22%\u201329%) group. In contrast, no significant differences were observed between the CONTROL (30%\u201337%) and PCOS (30%\u201337%) groups. Furthermore, the PCOS (30%\u201337%) group demonstrated lower sympathetic modulation than the PCOS (22%\u201329%) group. After APT, the PCOS (22%\u201329%) group increased in vagal modulation, while the PCOS (30%\u201337%) group increased in sympathetic modulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCOS affects vagal modulation; however, this effect may be masked at elevated levels of body fat. Additionally, the combination of excess body fat with endocrine\u2010metabolic dysregulation appears to reduce sympathetic modulation, possibly due to sympathetic drive hyperactivity. APT positively affected HRV in both PCOS groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15163","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:09:15Z","timestamp":1731323355000},"page":"178-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Women With Polycystic Ovary Syndrome and Excess Body Fat Exhibit Atypical Sympathetic Autonomic Modulation That is Partially Reversed by Aerobic Physical Training"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6527-2304","authenticated-orcid":false,"given":"Jo\u00e3o Vitor Martins","family":"Bernal","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catarine","family":"da Veiga","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella Vieira","family":"Philbois","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-7975","authenticated-orcid":false,"given":"Victor Barbosa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-733X","authenticated-orcid":false,"given":"Bruno Augusto","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tallys Eduardo Velasco","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiara","family":"Chinellato","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"S\u00e1nchez\u2010Delgado","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas y de la Salud Universidad de Santander Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada Clarice","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-0005","authenticated-orcid":false,"given":"Hugo Celso Dutra","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01516-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_95_18"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29912"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318093"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000197"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2018-0198"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"424","article-title":"Women With Polycystic Ovarian Syndrome Exhibit Reduced Baroreflex Sensitivity That May be Associated With Increased Body Fat","volume":"112","author":"Philbois S. 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