{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:34Z","timestamp":1740126094994,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Earlier work suggests Myoinositol (MI) and D\u2010chiro\u2010 inositol (DCI) imbalance in urine and plasma of diabetic patients, and their potential for monitoring insulin resistance. This study aimed to assess levels of Myoinositol (MI) and D\u2010chiro\u2010 inositol (DCI) in saliva of children with type 1 diabetes mellitus (DM\u20101) and controls, to verify if concentrations of MI and DCI are similarly altered in saliva, exploring their potential for monitoring DM\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>This cross\u2010sectional clinical study enroled 45 patients (DM\u20101, <jats:italic>n<\/jats:italic>\u2009=\u200925; Controls, <jats:italic>n<\/jats:italic>\u2009=\u200920). Children aged 3\u201312 years with fasting blood glucose levels &gt;\u2009126\u2009mg\/dL, and HbA1c levels &gt;\u20097%. Saliva was collected, and salivary measurements included pH, flow rates and concentrations of MI, DCI and glucose, employing high\u2010performance liquid chromatography. Periodontal health was assessed using bleeding and plaque indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with DM\u20101 showed elevated MI (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), reduced DCI (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and increased MI\u2010DCI ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The MI\u2010DCI ratio was elevated by 16\u2010fold among diabetic children. Plaque (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and gingival bleeding (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) were higher in DM\u20101 than controls. The MI increased the odds of an outcome of DM\u20101 by 174%, while DCI reduced the odds by 63%, highlighting their strong and opposing effects on DM\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with DM\u20101 express higher MI and lower DCI levels, while non\u2010diabetic children show an inversion of these concentrations. Inositol imbalance in saliva of diabetic children resembles previous results in urine, and represents a possible venue for monitoring this disease, paving the way for future investigations into salivary inositols.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15164","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T12:33:50Z","timestamp":1731933230000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imbalance of Myoinositol and D\u2010Chiro\u2010Inositol in Saliva of Children With Type\u20101 Diabetes Mellitus: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-1219","authenticated-orcid":false,"given":"Pedro Henrique Moreira","family":"Lima","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing Federal University of Ceara 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