{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:06:43Z","timestamp":1776287203132,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Vitamin D deficiency (VDD) in children can cause hypocalcaemia and rickets, but the prevalence of these complications and the 25\u2010hydroxyvitamin D (25OHD) concentrations below which they arise is uncertain. We investigated this in children (&lt;\u200918 years) with 25OHD measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Measurement and Patients<\/jats:title><jats:p>We obtained 25OHD results from the regional laboratory database, alongside albumin\u2010adjusted serum calcium (aCa), parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months of the index 25OHD. We defined confirmed VDD with biochemical abnormalities (VDDba) as all of low aCa, elevated PTH and elevated ALP. Possible\/potential VDDba were defined as 2\/3 VDDba criteria with the third test missing (possible), or in the normal range (potential). Clinical records of identified cases were reviewed, and a consensus diagnosis was reached.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30,663 25OHD measurements were identified over 11.5 years (1 January 2009 to 15 June 2020); mean age 8\u2009y, 47% female. After excluding ineligible results, 12,858 25OHD measurements from 9516 individuals with \u2265\u20092 aCa, PTH and ALP were analysed. Median 25OHD was 61\u2009nmol\/L; 36% &lt;\u200950\u2009nmol\/L, 10% &lt;\u200925\u2009nmol\/L. In total, 152 index 25OHD measurements were categorised as VDDba (30 confirmed, 23 possible and 99 potential). Following record review, 118 individuals (111\u2009&lt;\u20093 years) had 120 clinically confirmed VDDba episodes (62 clinical rickets, 15 biochemical rickets, 16 hypocalcaemia, 23 secondary hyperparathyroidism and 4 partially treated rickets). Fifty\u2010six had undetectable 25OHD, and 104\u2009&lt;\u200925\u2009nmol\/L. The proportion of clinically confirmed VDDba was 0.9% for all eligible 25OHD measurements, and 8% for 25OHD\u2009&lt;\u200925\u2009nmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VDDba is uncommon in children undergoing 25OHD testing, and occurs almost entirely in children &lt;\u20093 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15184","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T10:09:46Z","timestamp":1735294186000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of Vitamin D Deficiency With Biochemical Abnormalities in Children Undergoing Vitamin D Testing"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-2674","authenticated-orcid":false,"given":"Mark J.","family":"Bolland","sequence":"first","affiliation":[{"name":"Department of Medicine University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hofman","sequence":"additional","affiliation":[{"name":"Liggins Institute University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-0096","authenticated-orcid":false,"given":"Andrew","family":"Grey","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0437"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1867-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-2081-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511419"},{"key":"e_1_2_9_9_1","first-page":"374","article-title":"Characteristics of Children With Florid Vitamin D Deficient Rickets in the Auckland Region in 1998","volume":"113","author":"Blok B. H.","year":"2000","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12390"},{"key":"e_1_2_9_11_1","first-page":"86","article-title":"Vitamin D Deficiency, Supplementation and Testing: Have We Got It Right in New Zealand?","volume":"134","author":"Bolland M. J.","year":"2021","journal-title":"New Zealand Medical Journal"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.15184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:58:15Z","timestamp":1738580295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.15184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cen.15184"],"URL":"https:\/\/doi.org\/10.1111\/cen.15184","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"2024-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}