{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:07:16Z","timestamp":1790374036107,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to compare the clinical efficacy of dual\u2010time\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT with adrenal vein sampling (AVS) in PA lateralization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analysed 161 patients with PA. We assessed the diagnostic performance of dual\u2010time\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT in diagnosing unilateral primary aldosteronism (UPA) and aldosterone\u2010producing adenoma (APA). We also explored the relationship between\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT findings, postoperative outcomes, and the presence of the KCNJ5 gene mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The diagnostic accuracy of\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET at 10 and 40\u2009min for UPA (75.2% and 76.4%, respectively) surpassed that of CT (55.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The optimal cutoff for diagnosing APA was 10\u2009min lesion\u2010to\u2010normal adrenal ratio = 1.95, yielding an AUC of 91.9%, with sensitivity, specificity, and accuracy of 76.0%, 91.3%, and 83.3%, respectively. This high diagnostic efficacy extended to subgroups with nodules \u2265\u20091 or &lt;\u20091\u2009cm, and the largest AUC of\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT for diagnosis APA with lesions \u2265\u20091 and &lt;\u20091\u2009cm is 88.2% and 97.0%, respectively. The lateralization results provided by\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT corroborated the surgical treatment decision in 92.0% of PA patients, and more than 95% achieved clinical and\/or biochemical cure or improvement. The PET positive rate of KCNJ5 mutation was higher than that of KCNJ5 wild\u2010type, with optimal diagnostic efficacy at 40\u2009min lesion\u2010to\u2010liver ratio = 4.79 (AUC 81.3%, sensitivity 90.0%, specificity 66.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Dual\u2010time\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT exhibits robust diagnostic efficacy in PA lateralization. Furthermore,\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010pentixafor PET\/CT holds promise as an imaging marker for predicting the presence of the KCNJ5 mutation in PA patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.15204","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T02:39:35Z","timestamp":1737945575000},"page":"499-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Utility of Dual\u2010Time\n                    <sup>68<\/sup>\n                    Ga\u2010Pentixafor PET\/CT in Diagnosing and Subtyping Primary Aldosteronism"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-1356","authenticated-orcid":false,"given":"Rui","family":"Zuo","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-147X","authenticated-orcid":false,"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-3208","authenticated-orcid":false,"given":"Hua","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing 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