{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:51:28Z","timestamp":1792245088920,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Craniopharyngioma (CP) has mostly nonspecific symptoms, leading to delayed diagnosis. Early indicators of CP in children are needed for early diagnosis and to detect postoperative growth patterns for their optimal care. This study aimed to investigate the clinical characteristics and postoperative growth patterns in Japanese children with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective analysis of medical records (2000\u20132022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010three children (median age at diagnosis\u2009=\u20099.3 (0.9\u201318) years; 44 females) from Toranomon Hospital, Tokyo, Japan, who were diagnosed with CP and undergoing trans\u2010sphenoidal or trans\u2010cranial surgery, or both, were followed up for at least 3 years. We assessed clinical characteristics and changes in height and body mass index (BMI) standard deviation scores (SDSs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SDSs for height and BMI were \u22121.7 (\u22124.0 to 1.3) and 0.21 (\u22122.3 to 2.2), respectively. Chief complaints at diagnosis were neurologic (<jats:italic>n<\/jats:italic>\u2009=\u200925, 34.2%), endocrine (<jats:italic>n<\/jats:italic>\u2009=\u200922, 30.1%), or ophthalmic (<jats:italic>n<\/jats:italic>\u2009=\u200922, 30.1%), while accompanying neurologic, endocrine, and ophthalmic symptoms were present in 34 (46.6%), 63 (86.3%), and 37 (50.7%) patients, respectively. One year after surgery, growth without growth hormone (GWGH) was detected in seven patients (13%), which could be categorized based on MRI\u2010evident hypothalamic involvement (transient: <jats:italic>n<\/jats:italic>\u2009=\u20093, 5.6%; permanent: <jats:italic>n<\/jats:italic>\u2009=\u20094, 7.4%). Preoperative hydrocephalus (<jats:italic>n<\/jats:italic>\u2009=\u200921, 32.8%) was the only factor significantly associated with postoperative GWGH at 1 year (<jats:italic>p<\/jats:italic>\u2009=\u20090.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with CP have distinctive clinical characteristics and postoperative growth patterns. Identifying symptoms using school\u2010based auxological measurements could help in early diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15224","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:13:03Z","timestamp":1741709583000},"page":"673-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Characteristics and Postoperative Growth in Japanese Children with Craniopharyngioma"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1530-7860","authenticated-orcid":false,"given":"Yuri","family":"Mukoyama","sequence":"first","affiliation":[{"name":"Department of Paediatrics Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Moriguchi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Toranomon Hospital Tokyo 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