{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:53:06Z","timestamp":1780649586981,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Large\u2010scale population\u2010based data on the association between low high\u2010density lipoprotein cholesterol (HDL\u2010C) levels and the development of acromegaly are lacking. We aimed to investigate the association between different HDL\u2010C levels and incident acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>Using data from the National Health Insurance Services in Korea, we enroled adults without pre\u2010existing acromegaly, who participated in the national health screening in 2009, were enroled and followed up until 2019. Participants were classified based on baseline HDL\u2010C levels. Low HDL\u2010C level was defined as HDL\u2010C value\u2009&lt;\u200940\u2009mg\/dL for men or &lt;\u200950\u2009mg\/dL for women. The risk of acromegaly was also examined according to HDL\u2010C levels in 10\u2009mg\/dL intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among a total 9,876,423 adults without acromegaly, 459 (4.6 cases per 100,000 people) participants developed acromegaly during the median follow\u2010up period of 9.2 years. The risk of acromegaly was significantly higher in patients with low HDL\u2010C (HR 1.45, 95% CI 1.19\u20131.78) compared to normal HDL\u2010C group after adjusting for potential confounding variables, including total cholesterol levels and the use of lipid\u2010lowering medication. Furthermore, when HDL\u2010C levels were categorised into four groups at 10\u2009mg\/dL intervals, a dose\u2010dependent association with acromegaly risk was observed, with the highest risk found in the low HDL\u2010C group (grade 4, HR 1.78, 95% CI 1.30\u20132.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low HDL\u2010C levels were independently associated with an increased risk of acromegaly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15264","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T06:17:51Z","timestamp":1747030671000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010Density Lipoprotein Cholesterol Levels and the Risk of Acromegaly: A Nationwide Cohort Study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-5006","authenticated-orcid":false,"given":"Eun","family":"Roh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea"},{"name":"Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-8007","authenticated-orcid":false,"given":"Ji Hye","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-8084","authenticated-orcid":false,"given":"Han Na","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-0643","authenticated-orcid":false,"given":"Kyung\u2010Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science Soongsil University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-7251","authenticated-orcid":false,"given":"Jun Goo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-0799","authenticated-orcid":false,"given":"Seong Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-8476","authenticated-orcid":false,"given":"Sung\u2010Hee","family":"Ihm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00244-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0117"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.4.363"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04414.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2570"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.1.107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02081.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00115"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1917"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2780"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn387"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1032-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2023.102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.086"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39181-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab822"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2019.0223"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2022.0193"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23031"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-1550"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215687"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2021.044"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.428"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000146094.59640.13"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.4.481"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2013.08.001"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0365-5"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13285"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2259"},{"issue":"3","key":"e_1_2_10_34_1","first-page":"936","article-title":"Growth Hormone Inhibits Lipoprotein Lipase Activity in Human Adipose Tissue","volume":"80","author":"Ottosson M.","year":"1995","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-13"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2896"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.15264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:15:43Z","timestamp":1751526943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.15264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/cen.15264"],"URL":"https:\/\/doi.org\/10.1111\/cen.15264","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]},"assertion":[{"value":"2025-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}