{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:21:21Z","timestamp":1787498481748,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Pituitary radiotherapy (RT) is used for persistent\/recurrent Cushing's disease (CD) after pituitary surgery. The utility of late\u2010night salivary cortisol (LNSC) in evaluating endocrine remission after RT is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the clinical characteristics and outcomes of patients with CD after RT, in endocrine remission based on normal LNSC (group 1) or 24\u2009h urinary free cortisol (UFC; group 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Setting<\/jats:title>\n                    <jats:p>\n                      Retrospective cohort, observational study in academic medical centre. Patients (16\u221286 years old,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975) with CD who underwent RT were studied; group 1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916), group 2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), and 41 patients not in remission. Outcome measures included within\u2010group and between\u2010group changes (group 1 vs. group 2) in clinical characteristics, endocrine data and time to remission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five patients with CD, aged (median [range]: 50\u2009years [16, 86], 71% female, BMI: 34.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [19.1, 62.5], 63% with macroadenomas) underwent RT and 34 (45.3%) entered endocrine remission, including 16 (21.3%) in group 1 and 18 (24%) in group 2 (median: 56 months). From RT to remission, there were decreases in BMI (group 1: \u22123.9\u2009\u00b1\u20090.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001; group 2: \u22125.2\u2009\u00b1\u20091.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0123) and systolic blood pressure (group 1: \u22127.9\u2009\u00b1\u20093.9\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03; group 2: \u221210.1\u2009\u00b1\u20094.5\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). There were no between\u2010group differences in BMI, blood pressure, HbA1c, number of antihypertensive or antihyperglycemic agents, UFC, median time to remission, recurrence risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with CD following RT, LNSC appears to be clinically equivalent to UFC in the assessment of endocrine remission. These patients can be followed with LNSC, which is easier for patients to collect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.15270","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T02:38:21Z","timestamp":1747017501000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Late\u2010Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy"],"prefix":"10.1111","volume":"103","author":[{"given":"Ukasha","family":"Habib","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit and Neuroendocrine and Pituitary Tumor Clinical Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen A.","family":"Shih","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Radiation Oncology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-4622","authenticated-orcid":false,"given":"Beverly M. K.","family":"Biller","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit and Neuroendocrine and Pituitary Tumor Clinical Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-607X","authenticated-orcid":false,"given":"Nicholas A.","family":"Tritos","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit and Neuroendocrine and Pituitary Tumor Clinical Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts 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