{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:08:12Z","timestamp":1757617692072,"version":"3.44.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to evaluate the correlation between the fat\u2010to\u2010muscle ratio (FMR) and insulin resistance (IR) with aldosterone production among patients with idiopathic hyperaldosteronism (IHA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with primary aldosteronism\u00a0were screened from those with secondary hypertension and then subtyped via adrenal venous sampling. A total of 199 patients with IHA and 186 with essential hypertension (EH) (controls) were studied. Baseline clinical characteristics, including data on diabetes and IHA, were collected. The FMR was evaluated based on the distribution of adipose tissue and muscle, measured by a body composition analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of diabetes and prediabetes was significantly higher in patients with IHA compared to those with essential hypertension. IHA patients also had significantly higher hemoglobin A1c(HbA1c) levels, homeostatic model assessment of insulin resistance (HOMA\u2010IR), and much lower quantitative insulin sensitivity check index\u00a0scores than the EH group. FMR was positively associated with fasting insulin, HOMA\u2010IR, aldosterone\u2010to\u2010renin ratio (ARR), and age. A higher FMR was linked to the prevalence of IHA, with a stepwise increase in risk observed from the lowest to the highest quartiles of FMR. Logistic regression analysis showed that both HOMA\u2010IR and body mass index\u00a0contributed to the elevated FMR. IHA may result from a substantial loss of muscle mass accompanied by fat accumulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this retrospective study, our findings suggest that FMR could serve as a valuable metric for early intervention and comanagement strategies in patients at risk of sarcopenic obesity. This approach could help block the progression from aldosterone\u2010producing cell clusters to IHA, potentially inhibiting aldosterone overproduction in such patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15274","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:18:56Z","timestamp":1747725536000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Skeletal Fat\u2010to\u2010Muscle Ratio in Idiopathic Hyperaldosteronism"],"prefix":"10.1111","volume":"103","author":[{"given":"Yuhe","family":"Jiang","sequence":"first","affiliation":[{"name":"Business Analytics, College of Business Macau University of Science and Technology Macau China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie Chen","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Information University of Sheffield  South Yorkshire The UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruidong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6340-7360","authenticated-orcid":false,"given":"Caixia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00210-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010087"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2018.10.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944717711379"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13312"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00866"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00187"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15212"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2017003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020494"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10081027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12822"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002510"},{"key":"e_1_2_7_15_1","first-page":"727","article-title":"Expert Consensus on the Diagnosis and Treatment of Primary Aldosteronism","volume":"36","author":"Endocrinology C. So","year":"2020","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2023.04.023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346708"},{"issue":"01","key":"e_1_2_7_18_1","first-page":"33","article-title":"Relationship Between Insulin Resistance and Aldosterone Level in Patients With Metabolic Syndrome","volume":"17","author":"Cao C.","year":"2009","journal-title":"Chinese Journal of Diabetes"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1293"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad520"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04148.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00195"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01933-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0021-9"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-02006-w"},{"issue":"10","key":"e_1_2_7_26_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258922","article-title":"Relationship Between Obesity\u2010Related Anthropometric Indicators and Cognitive Function in Chinese Suburb\u2010Dwelling Older Adults","volume":"16","author":"F\u00fcrnsinn C.","year":"2021","journal-title":"PLoS One"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13054"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084110"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs290"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.109439"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018226"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.173"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-024-04941-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8932133"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028201"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.631848"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.15274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T10:02:50Z","timestamp":1757152970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.15274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/cen.15274"],"URL":"https:\/\/doi.org\/10.1111\/cen.15274","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"2025-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}