{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:39:49Z","timestamp":1775194789738,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thyroid nodules are less common in children than in adults; however, when diagnosed, they carry a greater risk of malignancy. The Bethesda System for Reporting Thyroid Cytopathology uses six cytological categories to predict thyroid nodule malignancy using fine\u2010needle aspiration. This study aimed to estimate the malignant potential of thyroid nodules in children using the Bethesda system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of 121 patients aged \u2264\u200919 years who underwent thyroid surgery following fine\u2010needle aspiration (FNA) of a suspicious nodule between 2001 and 2019 at two tertiary medical centres. All FNA specimens were evaluated and categorised according to the Bethesda classification system. The prevalence of malignancy for each cytological category was calculated and subsequently compared with the findings of the final pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age at the time of operation was 14.8 years, and 79.5% of the patients were female. The mean nodule size was 24.8\u2009mm. The distribution of nodules across Bethesda cytological categories, from B1 to B6, was as follows: 2, 50, 19, 17, 10, 23 nodules. An analysis of the final pathology reports revealed 66 malignant nodules (54.5%). The malignancy risk was 24% for nodules categorised as B2, 52.6% for nodules categorised as B3, 58.8% for nodules categorised as B4, and 100% each for nodules categorised as B5\u2010B6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that the malignancy rates for all categories of the Bethesda system were higher in paediatric patients than in adults, including a substantial proportion of cytologically benign nodules. Moreover, our observed rates exceeded those previously reported in comparable studies of the paediatric population, as indicated by the American Thyroid Association guidelines. We propose a more intensive approach for paediatric patients with suspected clinical or sonographic features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15280","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:38:11Z","timestamp":1748417891000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Malignancy Risk of Paediatric Thyroid Nodules Classified According to the Bethesda System"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-3635","authenticated-orcid":false,"given":"Katia","family":"Averbukh\u2010Oren","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Soroka University Medical Center Be'er Sheva Israel"},{"name":"Department of Medical Sciences Ben Gurion University of the Negev Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabri","family":"El\u2010Saied","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Soroka University Medical Center Be'er Sheva Israel"},{"name":"Department of Medical Sciences Ben Gurion University of the Negev Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Hod","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Schneider Children Medical Center of Israel, and Rabin Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Ritter","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Rabin Medical Center, Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u2010Zion","family":"Joshua","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Ben Gurion University of the Negev Beer Sheva Israel"},{"name":"Department of Otolaryngology Head and Neck Surgery Barzilai Medical Center Ashkelon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liran","family":"Stiler\u2010Timor","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Soroka University Medical Center Be'er Sheva Israel"},{"name":"Department of Medical Sciences Ben Gurion University of the Negev Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Shoffel\u2010Havakuk","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Rabin Medical Center, Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liora","family":"Lazar","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes Schneider Children's Medical Center of Israel Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Bachar","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Rabin Medical Center, Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/965212"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-15-10-1270"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00882"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1796"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161208.GL"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/6718.3913"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"issue":"9","key":"e_1_2_8_11_1","first-page":"1039","article-title":"The 2023 Bethesda System for Reporting Thyroid Cytopathology","volume":"33","author":"Ali S. 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