{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:16:13Z","timestamp":1790306173622,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite being a leading cause of secondary hypertension and association with a higher incidence of cardiovascular morbidity and mortality the prevalence of primary aldosteronism (PA) is poorly studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed the prevalence of PA in participants being treated as essential hypertension (EHTN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Participants<\/jats:title><jats:p>In this prospective, cross\u2010sectional study, 492 participants with diagnosis of EHTN were evaluated. The screening for PA was conducted by measuring plasma aldosterone concentration (PAC) and direct renin concentration (DRC), from which the aldosterone\u2010to\u2010renin ratio (ARR) was calculated. Based on Endocrine Society guidelines, screening test was followed by a confirmatory recumbent saline infusion test (SIT). Participants who showed a post\u2010SIT PAC greater than 5\u2009ng\/dL were diagnosed with PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 492 EHTN participants, 91 (18.49%) had positive screening test. Out of 91 participants, 59 agreed for SIT and PA was confirmed in 37 participants (8.04%) (Excluding 32 screened positive participants who were non\u2010compliant to SIT). The mean age was 49.98\u2009\u00b1\u20097.76 years, and median duration of hypertension was 5 (0\u221224) years. The prevalence of PA increased with grade of hypertension (5.97% in grade 1%\u221212.03% in grade 3), hypertension daily dose (HDD) (3.57% in those with HDD\u2009&lt;\u20091% to 27.27% in those with HDD\u2009\u2265\u20094). No significant difference in hypokalaemia in PA and EHTN (2.70% and 3.54% respectively, <jats:italic>p<\/jats:italic>: 0.7815).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows a high prevalence of PA in subjects treated as a case of EHTN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15296","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T01:58:57Z","timestamp":1751248737000},"page":"447-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of Primary Aldosteronism Among Patients With Hypertension"],"prefix":"10.1111","volume":"103","author":[{"given":"Divyansh","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasvini","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamoghna","family":"Ghosh","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prayas","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranveer Singh","family":"Jadon","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Canadian Specialist Hospital Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-2779","authenticated-orcid":false,"given":"Rajesh","family":"Khadgawat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00128-2"},{"key":"e_1_2_10_3_1","unstructured":"Iips IC. 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