{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T02:39:30Z","timestamp":1767494370754,"version":"3.44.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Longitudinal data on bone health in adolescents with Graves' disease (GD) are limited. Thus, we aimed to evaluate lumbar spine bone mineral density (LSBMD) and trabecular bone score (TBS) changes in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline and follow\u2010up LSBMD <jats:italic>Z<\/jats:italic>\u2010score (LSBMD<jats:sub>Z<\/jats:sub>) and TBS <jats:italic>Z<\/jats:italic>\u2010score (TBS<jats:sub>Z<\/jats:sub>) were measured. TBS was analysed using iNsight software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one adolescents with GD (age 13.7\u2009\u00b1\u20092.8 years, 73% female) were enroled. At baseline, 18% of adolescents with recently diagnosed GD (RGD, \u2264\u20096 months) had low LSBMD (median LSBMD<jats:sub>Z<\/jats:sub>: \u22120.7 [\u22121.5 to \u22120.4]), and 58% had low TBS (mean TBS<jats:sub>Z<\/jats:sub>: \u22121.5\u2009\u00b1\u20091.3). The median follow\u2010up duration was 2.2 (1.2\u20132.9) years. In the entire cohort, at follow\u2010up, LSBMD<jats:sub>Z<\/jats:sub> normalized, whereas TBS<jats:sub>Z<\/jats:sub> remained below zero (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Adolescents with RGD and those with longer disease duration had comparable LSBMD<jats:sub>Z<\/jats:sub> and TBS<jats:sub>Z<\/jats:sub> at follow\u2010up. When stratified by baseline disease duration tertiles, improvements in LSBMD<jats:sub>Z<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.013) and TBS<jats:sub>Z<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.035) progressively declined with increasing disease duration. LSBMD<jats:sub>Z<\/jats:sub> was significantly increased from baseline during 28 months of treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), while TBS<jats:sub>Z<\/jats:sub> improvement was observed during the initial 9 months (<jats:italic>p<\/jats:italic>\u2009=\u20090.046). Stepwise regression identified time\u2010weighted free thyroxine (FT4) as a negative predictor of \u2206TBS<jats:sub>Z<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low TBS was prevalent among adolescents recently diagnosed with GD. Despite observed improvements, TBS<jats:sub>Z<\/jats:sub> remained below zero at follow\u2010up, indicating incomplete recovery. As FT4 negatively impacts TBS improvement, maintaining optimal FT4 concentrations early in the disease is crucial for preserving bone microarchitecture in paediatric GD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.70004","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:04:38Z","timestamp":1753160678000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Changes in Bone Mineral Density and Trabecular Bone Score in Adolescents With Graves' Disease"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-6774","authenticated-orcid":false,"given":"Pattara","family":"Wiromrat","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nantaporn","family":"Wongsurawat","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratikorn","family":"Chaisiwamongkol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutapong","family":"Raruenrom","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyanan","family":"Suparattanagool","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouyporn","family":"Panamonta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatlert","family":"Pongchaiyakul","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500265"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760043503"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"3","article-title":"Thyroid Hormone Actions in Cartilage and Bone","volume":"2","author":"Williams G. 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