{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:11:00Z","timestamp":1759493460747,"version":"build-2065373602"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with hypercalcaemia, assessment of urinary calcium excretion helps differentiate primary hyperparathyroidism (PHPT) from familial hypocalciuric hypercalcaemia (FHH). For this, 24\u2009h calcium to creatinine clearance ratio (CCCR) is recommended, but others tests like random CCCR, 24\u2009h urine calcium excretion (UCE), and calcium to creatinine ratio (CR) are also frequently used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The survey objective was to evaluate current practice among UK endocrinologists and surgeons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A web\u2010based anonymous cross\u2010sectional survey, consisting of eight multiple\u2010choice questions was developed using Survey Monkey. The survey was disseminated to members of British Association of Endocrine and Thyroid Surgeons (BAETS) and Society for Endocrinology (SfE) between November 20, 2025 and December 19, 2024.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and sixty\u2010six responses from 210 endocrinologists and 56 surgeons were received (85% consultants). Respondents worked in both university (48.9%) and district hospitals (47.7%). The most commonly performed urine calcium test in hypercalcaemic patients was 24\u2009h UCE (58.6%), but for PHPT versus FHH differentiation, the most preferred test was 24\u2009h CCCR (43.6%), followed by random CCCR (24.8%), 24\u2009h UCE (14.3%), and CR (16.5%). Of respondents who had experience with using CCCR (<jats:italic>n<\/jats:italic>\u2009=\u2009235), most (55.6%) used a cut\u2010off of &gt;\u20090.01 to rule out FHH, while &gt;\u20090.02 cut off was used by 26.7% respondents. Most clinicians (70.3%) used albumin\u2010adjusted calcium for CCCR calculation, and 71.4% respondents considered vitamin D levels \u2265\u200950\u2009nmol\/L to be adequate for urinary calcium measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The survey provides valuable insight into current UK practice. 24 h and random CCCR are the most commonly used tests to exclude FHH, but overall, practice varies widely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.70008","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:19:41Z","timestamp":1754284781000},"page":"757-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary Calcium Measurement in Patients With Hypercalcaemia; Endocrine Physicians and Surgeons Survey Results From UK"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-0941","authenticated-orcid":false,"given":"Muhammad Fahad","family":"Arshad","sequence":"first","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"},{"name":"University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-2843","authenticated-orcid":false,"given":"Saba P.","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"},{"name":"University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-137718"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4677"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae225"},{"key":"e_1_2_5_5_1","unstructured":"\u201cHyperparathyroidism (Primary): Diagnosis Assessment and Initial Management \u201d NICE 2019 https:\/\/www.nice.org.uk\/guidance\/ng132."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.15116"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:38:40Z","timestamp":1759491520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,3]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/cen.70008"],"URL":"https:\/\/doi.org\/10.1111\/cen.70008","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2025,8,3]]},"assertion":[{"value":"2025-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}