{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:55:52Z","timestamp":1787727352772,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Balance impairment is an underrecognized complication of acromegaly with potentially serious consequences for affected patients. In this study, we aimed to assess the balance in patients with long\u2010term acromegaly compared to non\u2010acromegalic controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>Seventeen patients with acromegaly and 17 age\u2010 and sex\u2010matched controls were examined using a force platform measuring the Centre of Pressure area (CoP<jats:sub>area<\/jats:sub>) and velocity (CoP<jats:sub>velocity<\/jats:sub>), the timed up\u2010and\u2010go (TUG) test, hand grip and knee extension dynamometry, nerve conduction measurements, visual acuity tests, and questionnaires concerning fear of falling and joint pain (Falls Efficacy Scale [FES\u2010I] and Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]). Descriptive statistics and linear regression analyses were used to compare groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, participants with acromegaly (mean acromegaly duration 13 [\u00b18.8] years, latest mean IGF\u2010I standard deviation score 1.2 [\u00b11.59]) had significantly increased CoP<jats:sub>area<\/jats:sub> adjusted for neural and visual function. When performing a difficult executive task, the CoP<jats:sub>area<\/jats:sub> was impaired, both with (<jats:italic>\u03b2<\/jats:italic>: 2.24 [1.29; 3.92], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and without (<jats:italic>\u03b2<\/jats:italic>: 2.09 [1.02; 4.26], <jats:italic>p<\/jats:italic>\u2009=\u20090.04) a cushion under their feet, as compared to controls. Mean TUG time was significantly higher in patients with acromegaly than controls (<jats:italic>\u03b2<\/jats:italic>: 1.24 [0.07; 2.42], <jats:italic>p<\/jats:italic>\u2009=\u20090.04), and correlated with self\u2010reported joint pain (<jats:italic>\u03b2<\/jats:italic>: 0.04 [0.0004; 0.08], <jats:italic>p<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both static and dynamic balance is impaired in patients with long\u2010term controlled acromegaly, warranting clinical attention. Further studies are needed to address therapeutic options for this overlooked and potentially serious complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.70010","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T05:19:35Z","timestamp":1754457575000},"page":"703-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Static and Dynamic Balance Is Impaired in Patients With Long\u2010Term, Well\u2010Controlled Acromegaly: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-4387","authenticated-orcid":false,"given":"Christian","family":"Rosendal","sequence":"first","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-544X","authenticated-orcid":false,"given":"Annika 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