{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:57:30Z","timestamp":1772891850608,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A relationship among hypothyroidism and lipid disorders is well established. However, current evidence and guidelines do not support the use of thyroid hormones (TH) in euthyroid patients with hyperlipidaemia as potential harms are considerable. This European survey investigated the use of TH in euthyroid patients with severe hypercholesterolemia as a complementary treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Data were derived from the THESIS (Treatment of Hypothyroidism in Europe by Specialists) project that surveyed TH use. Univariable and multivariable analyses were used to explore associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 17,232 invitations, 5695 (33.0%) valid responses were received, and of these, 328 (5.8%) stated that TH are indicated in euthyroid patients with severe hypercholesterolemia. Univariable analyses disclosed significant differences and associations: (a) more non\u2010endocrinologists (8.9%) than endocrinologist (5.4%) used TH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), (b) the number of hypothyroid patients treated per year was inversely related to use of TH (<jats:italic>p<\/jats:italic>\u2009=\u20090.024), (c) members of international endocrine\/thyroid societies were more likely to use TH than non\u2010members (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), (d) significant variations by country and geographical region (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and (e) inverse relationship between gross national income per capita (GNIPC) and TH use (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariable analyses yielded significant associations between use of TH, and male gender, specialty and GNIPC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that a small but noteworthy minority of European thyroid specialists may be using TH to treat of severe hypercholesterolemia in euthyroid patients. If confirmed, this finding highlights the importance of raising awareness among thyroid specialists, professional societies, and healthcare providers to ensure adherence to evidence\u2010based practices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.70014","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T13:40:47Z","timestamp":1755006047000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thyroid Hormone Treatment for Hypercholesterolemia in Euthyroid Patients: Results From a European Survey of Thyroid Specialists"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-3566","authenticated-orcid":false,"given":"Juan C.","family":"Galofr\u00e9","sequence":"first","affiliation":[{"name":"Department of Endocrinology Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA) Pamplona Spain"},{"name":"Thyroid Task Force from the Sociedad Espa\u00f1ola de Endocrinolog\u00eda y Nutrici\u00f3n (SEEN) Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2017-0694","authenticated-orcid":false,"given":"Juan J.","family":"D\u00edez","sequence":"additional","affiliation":[{"name":"Thyroid Task Force from the Sociedad Espa\u00f1ola de Endocrinolog\u00eda y Nutrici\u00f3n (SEEN) Pamplona Spain"},{"name":"Department of Endocrinology Hospital Universitario Puerta de Hierro Majadahonda  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro Segovia de Arana Majadahonda Madrid Spain"},{"name":"Department of Medicine Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1417-287X","authenticated-orcid":false,"given":"Roberto","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Scientific Committee Associazione Medici Endocrinologi Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-6471","authenticated-orcid":false,"given":"Endre V.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-8709","authenticated-orcid":false,"given":"Tomasz","family":"Bednarczuk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-2733","authenticated-orcid":false,"given":"Enrico","family":"Papini","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Regina Apostolorum Hospital\u2010Lifenet Health Group Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-5970","authenticated-orcid":false,"given":"Milo\u0161","family":"\u017darkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Clinic of Endocrinology Diabetes and Diseases of Metabolism, UKCS Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-4530","authenticated-orcid":false,"given":"Roberto","family":"Negro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology V. 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