{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:13:47Z","timestamp":1762229627175,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Noninvasive follicular thyroid neoplasia with papillary\u2010like nuclear characteristics (NIFTP) is characterised by an indolent behaviour and was defined in 2016 to avoid overtreatment in differentiated thyroid cancer (DTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the clinicopathological characteristics and outcomes of patients with NIFTP treated at a Chilean centre between 2016 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of 1103 patients with thyroid neoplasia treated with surgery, 104 (9.42%) had NIFTP. Clinicopathological variables were recorded, including ultrasound characteristics, fine\u2010needle aspiration biopsy (FNAB) results, genetic testing when available, type of surgery, tumour size, and follow\u2010up data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 104 patients, 85 (81.7%) were female, age of 44\u2009\u00b1\u200914.2 years and a median tumour size of 1.7\u2009cm (range 0.1\u20137.1). Eighty\u2010six (82.7%) had available preoperative staging ultrasound: 1 (1.2%), 39 (45.3%), 38 (44.2%), and 8 (9.3%) were ACR\u2010TIRADS 2, 3, 4, and 5, respectively. Sixteen (15%) NIFTP were incidental, which were smaller than non\u2010incidental NIFTP (median 0.4\u2009cm (0.1\u20132.2) vs. 1.9\u2009cm (0.6\u20137.1),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Of the 86 FNAB results available, 2 (2.3%), 10 (11.6%), 20 (23.3%), 24 (27.9%), and 30 (34.9%) were Bethesda I, II, III, IV, and V, respectively. Forty\u2010three patients (41.3%) were treated with lobectomy, 58 (55.8%) with total thyroidectomy (TT), and only 3 (2.9%) with TT and lymph node dissection. In Bethesda II patients, surgery was indicated in cases of nodule growth, showing a larger tumour size than other Bethesda categories (3.0\u2009\u00b1\u20091.4 vs. 1.8\u2009\u00b1\u20091.02\u2009cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). ThyroidPrint\u00ae was performed in 12 patients with Bethesda III or IV, resulting suspicious in 11 (92%): of these, 8 (67%) underwent lobectomy. There were no significant differences between lobectomy and TT regarding sex, ACR\u2010TIRADS, tumour size, or ThyroidPrint\u00ae results. Twelve (11.5%) were multifocal and 5 (4.8%) bilateral. Fifty\u2010two patients (54%) were followed for \u2265\u20091 year using follow\u2010up criteria and response to treatment for low\u2010risk DTC recurrence. Thirty\u2010four (65%) had excellent response, 15 (28.8%) indeterminate (13 (25%) by biochemical criteria and 2 (3.8%) by ultrasound), 3 (5.7%) incomplete biochemical (2 (3.8%) due to elevated Tg and 1 (1.9%) due to elevated anti\u2010Tg antibodies), and none with incomplete structural response. There were no differences between lobectomy and TT \u00b1 lymph node dissection regarding the type of response. At the end of the follow\u2010up, there were no deaths, and no new interventions were required due to recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this series, NIFTP showed indolent behaviour and excellent prognosis. Ultrasonographically, 90% presented as ACR\u2010TIRADS 3 or 4, with less than 10% as ACR\u2010TIRADS 5. Regarding FNAB, nearly half were indeterminate, one\u2010third were Bethesda V, and none Bethesda VI. No significant differences in clinical outcomes were found between lobectomy and TT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70026","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T05:30:28Z","timestamp":1756099828000},"page":"888-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive Follicular Thyroid Neoplasia With Papillary\u2010Like Nuclear Characteristics (NIFTP): Clinico\u2010Pathological Analysis in a Chilean Centre"],"prefix":"10.1111","volume":"103","author":[{"given":"Iv\u00e1n","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00edn","family":"Sol\u00f3rzano","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Miguel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel Falc\u00f3n","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina Ruiz","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn Vi\u00f1ambres","family":"Giavio","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Cabello","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Montero","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n Gonz\u00e1lez","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonieta","family":"Solar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Cruz","family":"Olivos","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-7099","authenticated-orcid":false,"given":"Lorena Mosso","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Lustig","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6157-8055","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"CETREN: Centro de estudios traslacionales de Endocrinolog\u00eda UC Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01124-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0223"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.08.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ECL.2014.02.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2022.09.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0924-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0274"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0490"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.03.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0394"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25219"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01887-z"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-03905-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.1272"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9520-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0337"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0649"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27950"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-6903-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480907500104"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0555-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3846-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30694"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014129"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.08.013"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2024.0119"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae903"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.48104\/RVC.2022.75.2.8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ciresp.2018.02.017"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-17-0336"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:12:29Z","timestamp":1762229549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,24]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/cen.70026"],"URL":"https:\/\/doi.org\/10.1111\/cen.70026","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2025,8,24]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}