{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:20:15Z","timestamp":1767349215949,"version":"3.48.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Despite advances in neonatal care, delayed diagnosis and treatment of congenital hypothyroidism (CH) remain prevalent in regions lacking universal screening. This retrospective study evaluated catch\u2010up growth patterns in 65 children with a delayed diagnosis of CH. Study children were stratified into four groups based on age at thyroxine initiation: Groups A (&lt;\u20091 year), B (1\u2013&lt;3 years), C (3\u2013&lt;5 years), and D (5\u201310 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Growth outcomes, in terms of serial height\n                      <jats:italic>z<\/jats:italic>\n                      scores, skeletal maturation, proportion achieving catch\u2010up growth, and time to catch\u2010up, were assessed at baseline and after 3 years of thyroxine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within 3 years of treatment initiation, 64.6% (42\/65) of children achieved complete catch\u2010up in linear growth, and 56.9% (37\/65) attained optimum catch\u2010up. Among those treated before 1 year of age (Group A), 76% (19\/25) achieved complete and optimum catch\u2010up over a median (IQR) duration of 22 [12\u201333] months. In children diagnosed after 1 year of age (Groups B\u2013D combined), 57.5% (23\/40) attained complete catch\u2010up, of whom 78.3% (18\/23) achieved optimum growth, with time to catch\u2010up increasing progressively with later age at diagnosis (median range\u201425\u201334 months). The greatest change in height\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores was observed in the first\u2010year post\u2010treatment across all groups, with a decline thereafter. Catch\u2010up in skeletal maturation was observed in 72.3% (47\/65) of children and occurred earlier than catch\u2010up in linear growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early thyroxine initiation in CH is critical for optimal linear and skeletal growth. Delayed diagnosis is associated with slower, suboptimal recovery and an increased risk of compromised final adult height.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70038","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T05:50:27Z","timestamp":1758693027000},"page":"160-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catch\u2010Up Growth in Children With Congenital Hypothyroidism on Thyroxine Therapy: A Retrospective Study"],"prefix":"10.1111","volume":"104","author":[{"given":"Preeti","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pediatrics Lady Hardinge Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smriti","family":"Rohtagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics ESIC Hospital &amp; PGIMSR Basaidarapur New Delhi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev Kumar","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Delhi Cancer Registry BR Ambedkar IRCH, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-8835","authenticated-orcid":false,"given":"Anju","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lady Hardinge Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.4103\/2230-8210.98012"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1016\/j.lansea.2022.100040"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1111\/j.1365-2265.2006.02652.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1111\/j.1365-2265.1988.tb02892.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1111\/j.1365-2265.1983.tb00007.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1210\/endo-104-4-1107"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1203\/00006450-200111000-00014"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1210\/en.2007-0993"},{"key":"e_1_2_9_10_1","first-page":"1079","volume-title":"Williams Textbook of Endocrinology","author":"Underwood L. 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