{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:59:01Z","timestamp":1789469941294,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In boys, constitutional delay of growth and puberty (CDGP) has been associated with diverse negative psychosocial effects. Albeit alleviating distress is one of the main reasons for inducing pubertal development, the impact of puberty\u2010promoting treatment on psychosocial wellbeing is under\u2010researched. Our objective was to investigate the impact of puberty\u2010promoting therapies on the behavioural patterns as defined by the temperament characteristics emotionality, activity, and sociability (EAS) in boys with CDGP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The study is a randomized, controlled, open\u2010label trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      Thirty boys were randomized to receive either aromatase inhibitor letrozole (2.5\u2009mg\/day) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) or intramuscular testosterone (1\u2009mg\/kg\/every 4 weeks) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) for 6 months and followed up to 12 months. To compare our results with healthy peers, an age\u2010 and postal\u2010code matched, and a national reference population were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Temperament characteristics were evaluated with a standardized and validated questionnaire at 0\u2010, 6\u2010, and 12\u2010month visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In comparison to local peers, boys with CDGP were more withdrawn (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and experienced less anger (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and fear (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Compared to both local and national controls, there was a significant difference in emotionality, CDGP boys being less negatively emotional than peers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Sociability was higher in the Lz\u2010group in comparison to the T\u2010group both after the 6\u2010month treatment period (\u22120.48, 95% CI: 0.89; \u22120.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019) and at 12\u2010month follow\u2010up (\u22120.72, CI: 95%, \u22121.12; \u22120.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, boys with CDGP exhibited a generally docile temperament. The administration of puberty\u2010promoting treatments did not result in any adverse psychosocial effects on the temperament characteristics assessed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70039","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T04:35:27Z","timestamp":1759811727000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Puberty\u2010Promoting Treatment and Psychosocial Well\u2010Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-5694","authenticated-orcid":false,"given":"Laura","family":"Kariola","sequence":"first","affiliation":[{"name":"Helsinki University Hospital, New Children\u2032s Hospital Pediatric Research Center Helsinki 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University of Turku Turku Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Elovainio","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine University of Helsinki and Finnish Institute for Health and Welfare Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taneli","family":"Raivio","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital, New Children\u2032s Hospital Pediatric Research Center Helsinki Finland"},{"name":"Stem Cells and Metabolism Research Program (STEMM), Research Programs Unit, Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Medicum, Faculty of Medicine University of Helsinki Helsinki 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