{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:30:08Z","timestamp":1776821408019,"version":"3.51.2"},"reference-count":141,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify the link between environmental pollution and diabetes risk by focusing on pancreatic \u03b2\u2010cells as key targets of environmental insults, with emphasis on the role of endocrine\u2010disrupting chemicals (EDCs) in pancreatic dysfunction and diabetes pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This narrative review synthesises recent research on EDCs, focusing on their effects on \u03b2\u2010cells. The literature search included studies in English on EDCs, diabetes, and \u03b2\u2010cell function, utilising Boolean operators to refine the search.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EDCs impair \u03b2\u2010cell function through mechanisms such as oxidative stress, mitochondrial damage, and epigenetic changes. These pollutants disrupt insulin synthesis, secretion, and \u03b2\u2010cell survival, which is distinct from their general metabolic effects. Additionally, EDCs may interact synergistically with traditional diabetes risk factors, such as high\u2010fat diets, amplifying the risk of diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Environmental pollutants play a significant role in \u03b2\u2010cell dysfunction and diabetes, offering new directions for research and prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70050","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:16:35Z","timestamp":1760501795000},"page":"79-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Environmental Endocrine\u2010Disrupting Chemicals, Pancreatic \u03b2\u2010Cells, and Type 2 Diabetes Mellitus"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7486-8201","authenticated-orcid":false,"given":"Yan\u2010li","family":"Zhao","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Kunming University of Science and Technology Kunming P.R. 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