{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:15:06Z","timestamp":1787062506983,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) is a common cause of hypertension in young women. However, there is a paucity of data regarding its impact during pregnancy. The primary objective of this study was to describe the occurrence of hypertensive disorders of pregnancy (HDP) in PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This retrospective cohort study compared outcomes in pregnancies according to PA status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Pregnancies occurred between 2011 and 2022 at the Centre Hospitalier Universitaire de Sherbrooke. All selected pregnancies were screened for PA with an aldosterone\u2010to\u2010renin ratio (ARR) within a 5\u2010year period. Pregnancies with more than two fetuses and with other endocrinopathies were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>To ascertain PA diagnosis, ARR measurements were conducted, followed by a confirmatory test if abnormal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 226 studied pregnancies, 15 (6.6%) were diagnosed with PA. In the PA group, pre\u2010eclampsia was diagnosed in 46.7% of pregnancies (vs. 30.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.252), while gestational hypertension was diagnosed in 0.0% of pregnancies (vs. 16.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.136). Post\u2010partum HDP occurred in 40.0% of pregnancies with PA (vs 19.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.093). Additionally, 40.0% and 13.3% of pregnancies with PA respectively required intravenous antihypertensive treatment (vs. 24.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.216) and intensive care admission (vs. 3.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.113).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A trend towards an increased incidence of postpartum and severe pre\u2010eclampsia was noted in the PA group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70051","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:54:50Z","timestamp":1761540890000},"page":"113-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Retrospective Study on the Impact of Primary Aldosteronism in Pregnancy (H.A.P.P.I. Study Group)"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4905-2234","authenticated-orcid":false,"given":"Diana","family":"Oprea","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Lefran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9791-2118","authenticated-orcid":false,"given":"Matthieu","family":"St\u2010Jean","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire De Sherbrooke (CR\u2010CHUS) Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire De Sherbrooke (CR\u2010CHUS) Sherbrooke Qu\u00e9bec Canada"},{"name":"Department of Medicine, Division of Nephrology, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010\u00c8ve","family":"Roy\u2010Lacroix","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire De Sherbrooke (CR\u2010CHUS) Sherbrooke Qu\u00e9bec Canada"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Malick","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Luc","family":"Mallet","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Sauv\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire De Sherbrooke (CR\u2010CHUS) Sherbrooke Qu\u00e9bec Canada"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"},{"name":"Department of Medicine, Division of Internal Medicine, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14409"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30319-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30367-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30135-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3808"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2022.03.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2016.04.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814823-5.00025-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac311"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00139"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08952"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21983"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3353"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0704"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa606"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae155"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14137"},{"key":"e_1_2_8_20_1","unstructured":"Canadian Institute for Health Information. 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