{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:20:14Z","timestamp":1767349214762,"version":"3.48.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical outcome studies of 21\u2010hydroxylase deficiency congenital adrenal hyperplasia (21OHD CAH) may be subject to selection bias due to incomplete case ascertainment. This study aimed to develop a methodology for identifying existing CAH cases and explore its utility to study clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>17\u2010hydroxyprogesterone assays (17OHP) processed in NHS Greater Glasgow and Clyde between 2014 and 2022 were analysed based on 17OHP result (\u2265\u20096 or &lt;\u20096nmol\/L), location, test frequency and clinical details. Identified cases were cross\u2010referenced against local clinical data logs. For confirmed cases, current age, sex, age at diagnosis, mortality status, most recent blood pressure (BP) and anthropometry were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Assay results from 57,011 cases were extracted and, of these, 116 (F:M, 81:35) had confirmed CAH but 66 (57%) were not reported by any local clinical data logs. The median age at the time of the study was 33 years (range, 2, 75) and 95 (82%) were over 16 years (F:M, 69:26). In these adults, 52 (55%) were diagnosed in childhood (i.e. \u2264\u200916 years) and only 1 male was diagnosed in adulthood. The median body mass index (BMI) standard deviation score of children was 0.70 (\u22122.43, 3.15). Median BMI of adults was 28 (15, 56) and median adult and paediatric systolic BP was 120\u2009mmHg (95, 153) and 106\u2009mmHg (83, 130), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 17OHP\u2010based algorithm that was used in this study represents a useful method for identifying existing cases of CAH and can allow improved understanding of routinely collected markers of clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70058","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:16:23Z","timestamp":1763712983000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Routine Laboratory 17\u2010Hydroxyprogesterone for Identification of Cases of 21\u2010Hydroxylase Deficiency Congenital Adrenal Hyperplasia"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7235-8501","authenticated-orcid":false,"given":"Joseph","family":"McElvaney","sequence":"first","affiliation":[{"name":"Developmental Endocrinology Research Group, Royal Hospital for Children University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma R.","family":"Ali","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group, Royal Hospital for Children University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy R.","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Glasgow Royal Infirmary Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Longmuir","sequence":"additional","affiliation":[{"name":"West of Scotland Centre for Genomic Medicine Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"McNeilly","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Royal Hospital for Children Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Alimussina","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group, Royal Hospital for Children University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"McGowan","sequence":"additional","affiliation":[{"name":"West of Scotland Centre for Genomic Medicine Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-5549","authenticated-orcid":false,"given":"Syed","family":"Faisal Ahmed","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group, Royal Hospital for Children University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303070"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01865"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.46"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03330-w"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2022.1528"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns6030071"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns6030064"},{"key":"e_1_2_6_11_1","unstructured":"M. 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