{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:48:59Z","timestamp":1790668139258,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hypertriglyceridemia\u2010induced acute pancreatitis (HTG\u2010AP) is a severe and increasingly common form of pancreatitis requiring prompt triglyceride\u2010lowering therapy. This study aimed to evaluate the safety and effectiveness of a standardized fixed\u2010dose insulin drip protocol option implemented across a healthcare system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Multicenter retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      A total of 466 adult patients admitted with HTG\u2010AP between 15 July 2017, and 10 October 2024. Patients were divided into pre\u2010protocol (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009242) and post\u2010protocol (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009224) groups based on implementation of the fixed\u2010dose insulin protocol on 10 June 2021.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>The primary outcome was intensive care unit (ICU) length of stay. Secondary outcomes included hospital length of stay and time to achieve triglyceride levels &lt;\u20091000\u2009mg\/dL (11.3\u2009mmol\/L). Safety outcomes included incidence of hypoglycemia and hypokalemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline demographics were generally similar between groups, with higher rates of a history of diabetes and hyperlipidemia in the post\u2010protocol group. No statistically significant differences were observed in ICU length of stay, hospital length of stay, or time to triglyceride reduction. Mild hypoglycemia was more common post\u2010protocol (36.6% vs. 25.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), while rates of severe hypoglycemia and hypokalemia were low and comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The fixed\u2010dose insulin protocol demonstrated similar clinical outcomes to historical care with an acceptable safety profile. This protocol offers a reproducible and standardized approach to managing HTG\u2010AP in diverse inpatient settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70071","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T04:19:14Z","timestamp":1764908354000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of a Fixed\u2010Dose Insulin Protocol for Hypertriglyceridemia\u2010Induced Acute Pancreatitis: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8252-1021","authenticated-orcid":false,"given":"Neden","family":"Yacine","sequence":"first","affiliation":[{"name":"Department of Pharmacy Intermountain Medical Center Murray Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Chauv","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Intermountain Medical Center Murray Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa R.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Intermountain Medical Center Murray Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-1235","authenticated-orcid":false,"given":"Daniel B.","family":"Knox","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Intermountain Medical Center Murray Utah USA"},{"name":"Division of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lanspa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Intermountain Medical Center Murray Utah USA"},{"name":"Division of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin K.","family":"Grissom","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Intermountain Medical Center Murray Utah USA"},{"name":"Division of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah 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