{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:54:16Z","timestamp":1783050856586,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Prediabetes\u2014a reversible metabolic condition characterized by impaired fasting glucose, elevated HbA1c, or reduced glucose tolerance\u2014is a major precursor to type 2 diabetes mellitus (T2DM), especially in high\u2010risk populations like India. This review evaluates the impact of culturally tailored lifestyle interventions in preventing type 2 diabetes in adults with prediabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This PRISMA\u2010compliant systematic review (PROSPERO: CRD420251085667) included RCTs from 2020 to 2025 on adults (\u226518 years) with prediabetes. It assessed lifestyle interventions\u2014diet, exercise, yoga, and behavioral support\u2014using the Jadad scale and Downs &amp; Black checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six high\u2010quality RCTs demonstrated significant improvements in glycemic parameters, cardiometabolic profiles, and reductions in diabetes incidence. Yoga\u2010based protocols yielded notable declines in HbA1c and stress biomarkers. Dietary counseling and formula diets achieved normoglycemia and metabolic benefits independent of weight loss. Long\u2010duration interventions also reduced frailty and disability risks, enhancing overall health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Culturally adapted lifestyle interventions show strong efficacy and scalability in reversing prediabetes and reducing progression to T2DM. Integration of such strategies into national diabetes prevention programs may enhance sustainable metabolic health and address the unique needs of high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70077","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:22:51Z","timestamp":1765596171000},"page":"415-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201cPreventing the Progression: The Power of Lifestyle Interventions in Prediabetic Individuals\u2014A Systematic Review\u201d"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-9179","authenticated-orcid":false,"given":"Yashika","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"School of Health Sciences Chhatrapati Shahu Ji Maharaj University Kanpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5745-8853","authenticated-orcid":false,"given":"Munish","family":"Rastogi","sequence":"additional","affiliation":[{"name":"School of Health Sciences Chhatrapati Shahu Ji Maharaj University Kanpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-6445-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02703181.2012.656835"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-1009-0"},{"key":"e_1_2_10_6_1","unstructured":"International Diabetes Federation IDF Diabetes Atlas 11th ed. 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