{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:02:23Z","timestamp":1775473343467,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify pre\u2010treatment determinants of hypothyroidism and decision regret (DR) following radioiodine (RAI) therapy in Graves' disease (GD), and to assess their longitudinal impact on health\u2010related quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort of 500 GD patients receiving RAI. Machine learning models predicted hypothyroidism (3\/6 months) and high DR using clinical indices, socio\u2010economic factors, and ThyPRO\u201039 QoL scores. Longitudinal QoL was assessed at baseline, 3 and 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Unmarried (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), unemployed (35.50\u2009\u00b1\u200923.15 vs. 27.01\u2009\u00b1\u20096.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), and higher income patients (&gt;\u20095000 CNY\/month: 29.67\u2009\u00b1\u20096.94 vs. 26.10\u2009\u00b1\u20097.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) had significantly higher DR. Longer pre\u2010RAI medication (&gt;\u200912 months: 30.31\u2009\u00b1\u200915.96 vs. 27.48\u2009\u00b1\u200910.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) increased regret. Hypothyroidism models showed poor discrimination (AUC\u2009\u2264\u20090.59). DR prediction was robust (LR AUC\u2009=\u20090.81), driven by pre\u2010treatment stress (\u03b2\u2009=\u20091.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and anxiety (\u03b2\u2009=\u20090.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). QoL improved in goitre (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and hypermetabolic symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at 3 months, while overall QoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) improved by 6 months. Cognitive deficits persisted beyond 3 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010clinical factors (marital\/employment\/income status) and psychological states strongly predict post\u2010RAI regret. Hypothyroidism remains unpredictable, but high DR risk can be accurately identified (AUC\u2009=\u20090.81) for targeted intervention. Persistent cognitive impairment requires clinical attention despite biochemical normalisation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70092","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:37:42Z","timestamp":1768221462000},"page":"517-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality of Life and Decision Regret Risk in Graves' Disease After Radioactive Iodine Therapy: A Prospective Cohort Study"],"prefix":"10.1111","volume":"104","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19052"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2013.12.001"},{"key":"e_1_2_13_4_1","article-title":"Graves' Disease and Mental Disorders","volume":"19","author":"Atsushi F.","year":"2019","journal-title":"Journal of Clinical & Translational Endocrinology"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0479"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2019.11.01"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03279.x"},{"issue":"4","key":"e_1_2_13_8_1","article-title":"The Relationship Between Mental Fatigue, Depression, and Cognition in Graves' Disease","volume":"12","author":"Birgitta J.","year":"2023","journal-title":"European Thyroid Journal"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13611"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-023-00606-7"},{"issue":"2","key":"e_1_2_13_11_1","first-page":"89","article-title":"The Diagnostic Criteria of Graves' Disease and Especially the Thyrotropin Receptor Antibody; Our Own Experience","volume":"10","author":"Nebojsa P.","year":"2007","journal-title":"Hellenic Journal of Nuclear Medicine"},{"key":"e_1_2_13_12_1","unstructured":"Medicine. 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