{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:02:27Z","timestamp":1775473347021,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radioiodine therapy (RIT) is an effective treatment for Graves' disease (GD). However, some patients experience transient exacerbation of thyrotoxicosis in the mid\u2010to\u2010late\u2010phase period (2 weeks to several months post\u2010RIT), and its risk factors are poorly understood. This study aimed to investigate the clinical predictors of mid\u2010to\u2010late\u2010phase transient exacerbation of thyrotoxicosis following RIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study involving 200 Japanese patients with GD who received RIT at a single university hospital. Patients were categorized according to the clinical course as follows: no exacerbation, transient exacerbation or persistent exacerbation, likely due to residual or worsening GD. An exacerbation was defined as an increase of \u2265\u20091.0\u2009pg\/mL in free triiodothyronine (FT3) or \u2265\u20091.0\u2009ng\/dL in free thyroxine. Multivariable logistic regression, guided by the Akaike Information Criterion, was used to identify risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Transient thyrotoxicosis was observed in 62 patients (31.0%). Multivariate logistic regression identified a higher\n                      <jats:sup>131<\/jats:sup>\n                      I dose as a significant independent risk factor (odds ratio [OR]\u2009=\u20091.338, 95% confidence interval [CI]\u2009=\u20091.048\u20131.710,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). Although not statistically significant, high pre\u2010RIT FT3 levels and potassium iodide (KI) administration were identified as relevant predictors in the model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A higher\n                      <jats:sup>131<\/jats:sup>\n                      I dose was an independent risk factor for mid\u2010to\u2010late\u2010phase transient thyrotoxicosis after RIT. Higher pre\u2010RIT FT3 levels and KI use may contribute to this risk. Identifying patients with these factors may be helpful for closer post\u2010RIT monitoring to prevent complications and avoid misdiagnosing this transient event as a treatment failure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70093","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:19:56Z","timestamp":1767676796000},"page":"510-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010Treatment With Potassium Iodide and Higher Radioiodine Dose Are the Risk Factors of Mid\u2010to\u2010Late\u2010Phase Transient Thyrotoxicosis Following Radioiodine Therapy for Graves' Disease in Japanese Patients: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"104","author":[{"given":"Erika","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Medicine University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Medicine University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3093-0386","authenticated-orcid":false,"given":"Kazushi","family":"Maruo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Institute of Medicine University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fukazawa","sequence":"additional","affiliation":[{"name":"Department of Health Care Center Yurigaoka Mito Chuo Hospital Mito Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Medicine University of Tsukuba Tsukuba Ibaraki Japan"},{"name":"Tsukuba Clinical Research and Development Organization (T\u2010CReDO) University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikako","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Medicine University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Medicine University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Sugano","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Medicine University of Tsukuba Tsukuba Ibaraki 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