{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:03:42Z","timestamp":1791140622330,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Time\u2010restricted eating (TRE) represents a novel intervention that may improve hyperinsulinaemia and reduce weight, but has not been studied in polycystic ovarian syndrome (PCOS). In a randomised interventional study (NCT05126199 [1]), we investigated the feasibility of TRE in PCOS including recruitment, compliance, safety, drop\u2010out rate, and effect on insulin\u2010related parameters, anthropometrics, nutritional intake and metabolic indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were randomised to a 12\u2010week TRE regimen (18\u2009h fast\/6\u2009h eating window) or \u2018ad libitum\u2019 regimen (no time\u2010restriction), and then crossed over to the alternative regimen for a further 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TRE was a feasible intervention with near\u2010total compliance in those completing the intervention; however, there were considerable difficulties with recruitment. A total of 70 were eligible to participate, of which ultimately 15 were recruited, and 11 completed the study (4 [27%] drop\u2010outs due to commitment\/study duration). There were no serious adverse events in the TRE group. Compliance [%(SD)] with TRE was 94.7(4.5)%, and 10 participants were keen to continue the intervention post\u2010study. Whilst the study was not powered to detect changes in metabolic or anthropometric indices, exploratory analysis showed a decrease in HbA1c (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), weight (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), hip circumference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and waist circumference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) in the TRE group compared to the ad libitum eating group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a 12\u2010week cross\u2010over feasibility study, TRE was a safe and feasible intervention. Recruitment was challenging and with limited numbers, the TRE group showed a decrease in HbA1c and anthropometric indices compared to the \u2018ad libitum\u2019 group.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT05126199.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70094","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:32:06Z","timestamp":1768386726000},"page":"327-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Time\u2010Restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome (TimeMAP)"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-0945","authenticated-orcid":false,"given":"Ruair\u00ed","family":"Floyd","sequence":"first","affiliation":[{"name":"Department of 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