{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:55:43Z","timestamp":1787162143286,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperprolactinaemia has been linked to adverse metabolic profiles, but the metabolic consequences of prolactin (PRL) normalisation remain insufficiently characterised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate changes in anthropometric, blood pressure, and metabolic parameters following PRL normalisation, with analyses stratified by sex and age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 445 patients (286 women, 159 men) treated with cabergoline who had paired clinical and biochemical measurements before and after PRL normalisation. Pre\u2013post differences were assessed overall and stratified by sex and age (&lt;\u200950 vs. \u2265\u200950 years). Additional multivariable models examined independent predictors of metabolic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Men exhibited more severe baseline disease, including higher PRL levels, greater prevalence of macroadenomas, hypopituitarism, and cardiometabolic comorbidities. After PRL normalisation, body weight, BMI, and blood pressure showed no clinically relevant changes. Small but statistically significant reductions were observed in total cholesterol (185\u2009\u2192\u2009181\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), LDL\u2010C (110\u2009\u2192\u2009106\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), and triglycerides (91\u2009\u2192\u200982\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). These lipid changes, however, were not independently explained by sex, age, PRL dynamics, cabergoline exposure, or gonadal status in multivariable analyses. Fasting glucose and HDL\u2010C remained largely unchanged. By contrast, the TyG index decreased significantly across sexes and age groups, and multivariable modelling identified higher initial cabergoline dose and baseline hypogonadism as independent determinants of greater TyG reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRL normalisation with cabergoline was associated with modest improvements in conventional lipid fractions and a more consistent reduction in the TyG index, suggesting a preferential impact on insulin\u2010resistance\u2010related pathways. The absence of independent effects of sex, age, PRL dynamics, or cabergoline exposure on lipid changes underscores the need for cautious interpretation of statistically significant but small absolute shifts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70095","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:10:56Z","timestamp":1768450256000},"page":"483-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex\u2010 and Age\u2010Specific Metabolic Outcomes of Prolactin Normalisation in Hyperprolactinaemia"],"prefix":"10.1111","volume":"104","author":[{"given":"Pedro","family":"Iglesias","sequence":"first","affiliation":[{"name":"Endocrinology &amp; Nutrition Department Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda Madrid 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Gonz\u00e1lez","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Endocrinology &amp; Nutrition Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fern\u00e1ndez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Endocrinology &amp; Nutrition Department Complexo Hospitalario Universitario de Ourense Ourense Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia P\u00e9rez","family":"Castro","sequence":"additional","affiliation":[{"name":"Endocrinology &amp; Nutrition Department Complejo Hospitalario Universitario de Vigo Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Villar\u2010Taibo","sequence":"additional","affiliation":[{"name":"Endocrinology &amp; Nutrition Department Hospital Universitario de Santiago, Santiago de Compostela 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