{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:11:29Z","timestamp":1784279489952,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The bone health significance of incidentally detected low serum 25(OH)D in clinically asymptomatic individuals is debatable. We investigated the changes in bone mineral density (BMD) and trabecular bone score (TBS) after 1 year of cholecalciferol and calcium supplementation in asymptomatic individuals with low serum 25(OH)D and TBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Setting<\/jats:title>\n                    <jats:p>Interventional longitudinal study at the tertiary\u2010care centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Measurements<\/jats:title>\n                    <jats:p>\n                      The study subjects were 50 healthy individuals (age 45\u2009\u00b1\u20099 years, BMI 26.7\u2009\u00b1\u20093.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and M:F\u2009=\u200929:21) with serum 25(OH)D\u2009&lt;\u200950 nmol\/L and low TBS (&lt;\u20091.310) followed from an earlier study designed for generating TBS norms for Asian Indians. Participants received supervised 60,000 IU of cholecalciferol\/week for 8 weeks, followed by 60,000 IU\/month for the next 10 months and 500\u2009mg daily elemental calcium. Serum 25(OH)D and related biochemical parameters, BMD, and TBS were evaluated before and after 6\u2010 and 12\u2010months of supplementation. Changes were analysed using a generalised estimating equation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean serum 25(OH)D (nmol\/L) showed a significant rise following supplementation (29.1\u2009\u00b1\u200911.7 at baseline to 68.8\u2009\u00b1\u200947.4 and 63.2\u2009\u00b1\u200922.2 at 6\u2010 and 12\u2010months, respectively). Serum intact PTH, osteocalcin, and alkaline phosphatase showed a significant decrease within 6 months of supplementation. BMD improved significantly from baseline at lumbar\u2010spine, total\u2010hip, and femoral\u2010neck at 6\u2010 and 12\u2010months after supplementation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 for all). However, the mean TBS showed no significant change following cholecalciferol and calcium supplementation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One year of cholecalciferol and calcium supplementation in asymptomatic individuals resulted in a significant rise in serum 25(OH)D, which was associated with increased BMD but not TBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70100","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:26:22Z","timestamp":1769768782000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["One Year Cholecalciferol and Calcium Supplementation Improve BMD But Not Trabecular Bone Score in Asymptomatic Hypovitaminosis D"],"prefix":"10.1111","volume":"104","author":[{"given":"Soma","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Vishal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasenathipathy","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshpal Singh","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Clinical Epidemiology Sitaram Bhartia Institute of Science and Research New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-5074","authenticated-orcid":false,"given":"Ravinder","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30265-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2035"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2340"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13507"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.2.472"},{"key":"e_1_2_10_7_1","first-page":"755","article-title":"Presence of 25(OH) D Deficiency in a Rural North Indian Village Despite Abundant Sunshine","volume":"56","author":"Goswami R.","year":"2008","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-016-0739-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.15122"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1824-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.05.016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0558-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2734"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508921711"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.361"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2019.07.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01818-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_2_10_21_1","volume-title":"Technical Report. World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield","year":"2007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.499"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114086"},{"key":"e_1_2_10_24_1","first-page":"45","volume-title":"Nutritive Value of Indian Foods","author":"Gopalan C.","year":"1996"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1411"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.12.062"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3958"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac068"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2005.11.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2024.04.002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0481-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-025-07421-4"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:51:20Z","timestamp":1775469080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/cen.70100"],"URL":"https:\/\/doi.org\/10.1111\/cen.70100","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}