{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:38:05Z","timestamp":1782139085806,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital adrenal hyperplasia (CAH) is a chronic endocrine disorder affecting adrenal steroidogenesis, often requiring lifelong glucocorticoid therapy. Its impact on health\u2010related quality of life (HRQoL) in pediatric patients is inconsistent in the literature, with limited data from specific populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare HRQoL in children and adolescents with CAH to healthy peers, and to evaluate the influence of age, sex, ambiguous genitalia, and glucocorticoid dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional case\u2010control study included 25 children and adolescents with CAH (aged 5\u201318 years) and 25 healthy controls frequency\u2010matched for age and sex. HRQoL was assessed using the Pediatric Quality of Life Inventory (PedsQL\u2122 4.0) via child self\u2010reports and parent proxy reports. Participants were grouped by age: 5\u20136, 7\u201312, and 13\u201318 years. Clinical data, including, presence of ambiguous genitalia, and glucocorticoid dose, were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, HRQoL scores were similar between CAH patients and controls. Age\u2010stratified analysis showed that children aged 7\u201312 years with CAH reported higher physical functioning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) and total HRQoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) compared to controls. Adolescents with CAH reported significantly lower school functioning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), while other domains were comparable. No significant differences in HRQoL were observed by sex, ambiguous genitalia, or glucocorticoid dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children and adolescents with CAH generally achieve HRQoL comparable to healthy peers under adequate treatment. Age\u2010specific differences suggest younger children may experience preserved or enhanced physical well\u2010being, while adolescents are vulnerable to reduced school functioning. These findings highlight the need for multidisciplinary, age\u2010sensitive management strategies that include psychological and academic support, especially during adolescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70101","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:20:47Z","timestamp":1771482047000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality of Life in Children With Congenital Adrenal Hyperplasia: A Tertiary\u2010Center Case\u2010Control Study"],"prefix":"10.1111","volume":"104","author":[{"given":"\u00d6zlem","family":"Nalbanto\u011flu","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology University of Health Sciences, Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-3494","authenticated-orcid":false,"given":"\u00d6zge","family":"K\u00f6pr\u00fcl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University of Health Sciences, Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Yavuzy\u0131lmaz","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University of Health Sciences, Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-8868","authenticated-orcid":false,"given":"\u0130brahim Mert","family":"Erba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University of Health Sciences, Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7406-3307","authenticated-orcid":false,"given":"G\u00fcl\u015fen","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University of Health Sciences, Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-1768","authenticated-orcid":false,"given":"Nagihan Cevher","family":"Binici","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, University of Health Sciences Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzat","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University of Health Sciences, Dr. Beh\u00e7et Uz Children's Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1122435"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"54","article-title":"Psychosocial Development, Sexuality and Quality of Life in Congenital Adrenal Hyperplasia","volume":"17","author":"U\u00e7ar A.","year":"2025","journal-title":"Journal of Clinical Research in Pediatric Endocrinology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae068"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0769-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2012-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2019-0345"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.06.017"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.101"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.08.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435855"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01865"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2023.06.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"issue":"1","key":"e_1_2_6_15_1","first-page":"66","article-title":"Psychiatric Manifestations in Young Females With Congenital Adrenal Hyperplasia in Taiwan","volume":"31","author":"Liang H. 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