{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:11:47Z","timestamp":1788790307943,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271\u2010TRR\/CRC 205\u20101\/2"],"award-info":[{"award-number":["314061271\u2010TRR\/CRC 205\u20101\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) has been linked with reduced health\u2010related quality of life (QoL) and increased prevalence of anxiety and depression. While most studies compared patients with PA to healthy subjects, this study focused on comparison with hypertensive patients without PA to identify PA\u2010specific effects. Furthermore, the impact of targeted therapy on QoL and mental health was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mental and physical health\u2010related QoL, anxiety and presence of depressive and panic symptoms were assessed using the SF\u201012, GAD\u20107 and PHQ questionnaires in 925 patients with arterial hypertension tested for PA in a prospective, multi\u2010center international prospective cohort study. Questionnaires were assessed at baseline as well as 3\u22126 months after initiation of targeted therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst 833 of 925 patients who completed the necessary diagnostic procedures, 211 were diagnosed with PA. 98 of 116 patients with unilateral PA received unilateral adrenalectomy. At baseline, QoL, anxiety and mental health scores did not differ in patients with PA vs patients with hypertension without PA. At outcome assessment, SF\u201012 mental and physical component summaries as well as GAD\u20107 specifically improved in patients with unilateral PA after adrenalectomy (mean \u0394\u2009=\u20094.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018, \u0394\u2009=\u20093.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038 and \u0394\u2009=\u2009\u22121.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006, respectively) in contrast to no improvement in patients with PA on MRA treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no difference in health\u2010related QoL, anxiety and mental health in patients with hypertension with versus without PA. Unilateral adrenalectomy but not medical therapy improved health\u2010related QoL and decreased anxiety in patients with PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70106","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:08:07Z","timestamp":1773029287000},"page":"24-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improvement of Health\u2010Related Quality of Life and Mental Health After Unilateral Adrenalectomy for Primary Aldosteronism"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8560-9920","authenticated-orcid":false,"given":"Sybille","family":"Fuld","sequence":"first","affiliation":[{"name":"Department of Medicine III University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Adolf","sequence":"additional","affiliation":[{"name":"Department of Medicine IV University Hospital, Ludwig Maximilians University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Schulze","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Digital Sciences (CIDS) Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Br\u00fcdgam","sequence":"additional","affiliation":[{"name":"Department of Medicine IV University Hospital, Ludwig Maximilians University  Munich Germany"},{"name":"Department of Internal Medicine I Division of Endocrinology and Diabetes, BG Universit\u00e4tsklinikum Bochum, Ruhr\u2010Universit\u00e4t Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina T.","family":"Fuss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes University Hospital, University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Remde","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes University Hospital, University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"K\u00fcrzinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes University Hospital, University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0601-4334","authenticated-orcid":false,"given":"Sven","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH) Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-4976","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Metabolism Hudson Institute of Medical Research Clayton Australia"},{"name":"Department of Medicine Monash University Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Prince of Wales Hospital Randwick Australia"},{"name":"The George Institute for Global Health University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Department of Medicine IV University Hospital, Ludwig Maximilians University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Department of Medicine IV University Hospital, Ludwig Maximilians University  Munich Germany"},{"name":"Department of Endocrinology Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH) Zurich Switzerland"},{"name":"The LOOP Medical Research Center Zurich 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