{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:34:02Z","timestamp":1787582042562,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Crooke cell adenomas (CCAs) are considered rare and potentially aggressive variants of corticotroph adenomas. However, data on their clinical behaviour remain limited. This study aimed to compare the clinical, biochemical, radiological, and surgical outcomes of patients with CCAs and non\u2010CCA Cushing's disease (CD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients diagnosed with CD at our tertiary Pituitary Centre. Clinical presentation, baseline biochemical characteristics, tumour size, Ki\u201067 index, remission rates, recurrence, and presence of residual tumour on follow\u2010up MRI were compared between CCA and non\u2010CCA groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, patients with CCAs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) and non\u2010CCAs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960) demonstrated comparable biochemical profiles, except for ACTH levels, which were higher in the CCA group compared with the non\u2010CCA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Remission and recurrence rates at 3, 6, and 12 months did not differ significantly between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all). However, CCAs tended to present with larger tumour sizes and higher Ki\u201067 proliferation indices than non\u2010CCAs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.055 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05, respectively). Moreover, residual pituitary lesions were more frequently detected on follow\u2010up MRI among patients with CCA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that CCAs may not be as aggressive as previously assumed with respect to biochemical remission and recurrence rates. Nonetheless, their larger tumour size, higher proliferative index, and increased likelihood of residual disease underscore the importance of careful long\u2010term follow\u2010up. Further multicenter studies are warranted to better characterize the clinical course of CCAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70121","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:23:46Z","timestamp":1773030226000},"page":"647-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Crooke Cell Adenoma: Is Its Aggressiveness Overestimated? Evidence From a Single\u2010Centre Experience"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-0535","authenticated-orcid":false,"given":"Ilkin","family":"Muradov","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-5418","authenticated-orcid":false,"given":"Serdar","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"},{"name":"Pituitary Center Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2528-2353","authenticated-orcid":false,"given":"Sumeyye","family":"Akpinar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-5898","authenticated-orcid":false,"given":"Ali","family":"Tunc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9281-1771","authenticated-orcid":false,"given":"Banu Betul","family":"Kocaman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-4721","authenticated-orcid":false,"given":"Lala","family":"Soltanova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6837-0097","authenticated-orcid":false,"given":"Cansu Turker","family":"Saricoban","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-1757","authenticated-orcid":false,"given":"Nil","family":"Comunoglu","sequence":"additional","affiliation":[{"name":"Pituitary Center Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"},{"name":"Department of Pathology, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-9443","authenticated-orcid":false,"given":"Necmettin","family":"Tanriover","sequence":"additional","affiliation":[{"name":"Pituitary Center Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"},{"name":"Department of Neurosurgery, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-8628","authenticated-orcid":false,"given":"Nurperi","family":"Gazioglu","sequence":"additional","affiliation":[{"name":"Pituitary Center Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"},{"name":"Department of Neurosurgery, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa (retiree) Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-7941","authenticated-orcid":false,"given":"Hande Mefkure","family":"Ozkaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"},{"name":"Pituitary Center Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-140X","authenticated-orcid":false,"given":"Pinar","family":"Kadioglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"},{"name":"Pituitary Center Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00235-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314297"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443861"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-41"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1197-6380"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb02486.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.650791"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.11.049"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9498-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09703-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030871"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa564"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0695-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-16-0029"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.947085"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.64"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2023.09.076"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-025-02702-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401542"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.11.049"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP301360"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-025-01566-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.657382"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:59:58Z","timestamp":1777431598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,8]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/cen.70121"],"URL":"https:\/\/doi.org\/10.1111\/cen.70121","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,8]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}