{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:12:17Z","timestamp":1788790337165,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Papillary thyroid carcinoma (PTC) with T4aM0 stage, which involves extrathyroidal extension without distant metastasis, presents challenges in treatment management. While radioactive iodine (RAI) therapy has been shown to benefit certain high\u2010risk thyroid cancer patients, its effect on cancer\u2010specific survival (CSS) in T4aM0 PTC patients remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aim to evaluate the impact of RAI therapy on CSS in T4aM0 PTC patients following total thyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>1938 PTC patients with T4aM0 stage who underwent total thyroidectomy in the SEER database were identified. Clinical\u2010pathological and CSS data were systematically collected. Patients were stratified into the RAI\u2010treated group and the non\u2010RAI\u2010treated group. Propensity score matching (PSM) was implemented with 1:1 nearest\u2010neighbour matching to balance baseline covariates. Intergroup comparisons of demographic and clinical characteristics were performed in the entire cohort and PSM cohort. Subset analyses were conducted to indicate the effect of RAI therapy on CSS in different subgroups. Cox proportional hazards regression models were employed to evaluate CSS outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, 472 pairs of patients were included in the analysis. In both the entire cohort and the PSM cohort, no significant difference in CSS was observed between RAI\u2010treated and non\u2010RAI\u2010treated patients (HR\u2009=\u20090.797, 95% CI: 0.540\u20131.175,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.252; HR\u2009=\u20090.709, 95% CI: 0.437\u20131.151,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.709). Subgroup analysis also showed no survival benefit of RAI across various clinical characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RAI therapy does not significantly improve cancer\u2010specific survival in T4aM0 PTC patients after total thyroidectomy. These findings suggest that RAI may not be necessary for this subgroup, advocating for more individualised treatment approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70123","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:00:21Z","timestamp":1773032421000},"page":"93-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Radioactive Iodine Therapy on Cancer\u2010Specific Survival of Papillary Thyroid Carcinoma With T4aM0 Stage"],"prefix":"10.1111","volume":"105","author":[{"given":"Pengyu","family":"Li","sequence":"first","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"},{"name":"Department of Ultrasound, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"},{"name":"Sports Medicine Center, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5413-9129","authenticated-orcid":false,"given":"Tao","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-5670","authenticated-orcid":false,"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30172-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eprac.2024.06.003","article-title":"Controversies in the Management of Intermediate\u2010Risk Differentiated Thyroid Cancer","author":"Toro\u2010Tobon D.","year":"2024","journal-title":"Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/10507256251363120"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/481568"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25683"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16173096"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.0288"},{"key":"e_1_2_10_9_1","unstructured":"F. F.Palot ManzilandH.KaurRadioactive Iodine for Thyroid Malignancies. In: StatPearls. Treasure Island (FL) Relationships With Ineligible Companies. Disclosure: Harleen Kaur Declares No Relevant Financial Relationships With Ineligible Companies: StatPearls Publishing Copyright \u00a92024 StatPearls Publishing LLC; 2024."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-21-0046"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302009000700014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.1229"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20656"},{"key":"e_1_2_10_14_1","first-page":"1044","article-title":"Risk Factors for Recurrence and Survival Analysis in Locally Advanced T4a Papillary Thyroid Carcinoma After R0 Resection","volume":"57","author":"Chen J.","year":"2022","journal-title":"Zhonghua er bi yan hou tou jing wai ke za zhi"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/10507256251363120"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00321-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.04.059"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42083-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03496-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad580"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26637"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-04026-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-21-0161"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.04.002"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:16:04Z","timestamp":1788786964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,8]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/cen.70123"],"URL":"https:\/\/doi.org\/10.1111\/cen.70123","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,8]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}