{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:11:14Z","timestamp":1788790274265,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiofrequency ablation (RFA) has become an established minimally invasive treatment for benign thyroid nodules (BTN), offering excellent safety and efficacy. However, factors predicting treatment success and post\u2010procedural thyroid dysfunction remain incompletely understood. This study aimed to perform a preliminary evaluation of clinical, procedural, and biochemical predictors of RFA outcomes in a real\u2010world consecutive patient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on consecutive patients who underwent ultrasound\u2010guided RFA for cytologically benign thyroid nodules between January 2018 and March 2024 at a single tertiary medical centre. Demographic, sonographic, procedural, and biochemical variables, including thyroid\u2010stimulating hormone (TSH), thyroglobulin (Tg), and anti\u2010Tg antibodies, were analysed. The primary endpoint was the Volume Reduction Ratio (VRR), with \u2265\u200950% defined as procedural success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010two patients (mean age 52.6 years; 85.5% female) were included. The median best VRR achieved was 61.9% (IQR 46.6\u201374.5), with 71% of patients attaining \u2265\u200950% reduction. Higher pre\u2010treatment Tg levels were significantly associated with reduced VRR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and remained independently associated with procedural failure in an exploratory multivariable model (OR 0.87 per 10\u2009ng\/mL increase,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Pretreatment TSH levels showed a univariate positive trend but did not reach statistical significance on multivariate analysis. Two patients (3.2%) developed hypothyroidism post\u2010RFA, both with positive anti\u2010Tg antibodies (total 13 patients had positive anti Tg Ab). The overall complication rate was 6.5%, with no major adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that pre\u2010treatment thyroglobulin levels may serve as a potential biochemical predictor of RFA success in benign thyroid nodules, while antibody positivity may suggest susceptibility to post\u2010ablation hypothyroidism. While most existing literature focuses on imaging features (e.g., sonographic features) or surgeon technique, our findings highlight the unique importance of biochemical characteristics. Incorporating biochemical profiling into pre\u2010procedural assessment could refine patient selection and enhance individualised treatment planning. Future prospective studies are warranted to validate Tg as a biomarker of RFA response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70125","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:27:02Z","timestamp":1773034022000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Failure Predictors in Thyroid Nodule Radiofrequency Ablation Using Multivariate Analysis: A Single\u2010Centre Experience"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9781-5991","authenticated-orcid":false,"given":"Shmuel","family":"Wechsler","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shamir Medical Centre Be'er Ya'akov Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Shcherbaeva","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shamir Medical Centre Be'er Ya'akov Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-5774","authenticated-orcid":false,"given":"Jacob","family":"Pitaro","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shamir Medical Centre Be'er Ya'akov Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limor Muallem","family":"Kalmovich","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shamir Medical Centre Be'er Ya'akov Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02162.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2004.14.953"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004659"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.1.167"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2023.05.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26960"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508484"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.632"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2021.1993358"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.35.2.339"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-0880-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2018.1430868"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05044-5"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0685"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-023-01044-z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.07.046"},{"key":"e_1_2_12_19_1","article-title":"Radiofrequency Ablation for Symptomatic, Non\u2010Functioning, Thyroid Nodules: A Single\u2010Center Learning Curve","volume":"11","author":"Bom W. J.","year":"2021","journal-title":"Endocrine Connections"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005594"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-022-09743-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaf077"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(99)80078-9"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0184-8"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0344"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-008-9053-2"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1121"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs-22-539"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02598-6"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:15:46Z","timestamp":1788786946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,8]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/cen.70125"],"URL":"https:\/\/doi.org\/10.1111\/cen.70125","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,8]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}