{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:12Z","timestamp":1791363312485,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271\u2010TRR\/CRC 205\u20101\/2"],"award-info":[{"award-number":["314061271\u2010TRR\/CRC 205\u20101\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Subtyping of primary aldosteronism usually requires adrenal vein sampling (AVS). Interpretation can be compromised by apparent bilateral aldosterone suppression (ABAS), which we hypothesised reflects an artefact of the Liaison immunoassay of aldosterone. We therefore compared measurements of aldosterone by liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) with those by Liaison and iSYS immunoassays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational multicentre study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>The study involved 216 patients who underwent bilaterally selective non\u2010stimulated AVS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Adrenal and peripheral venous plasma aldosterone concentrations were measured by Liaison and iSYS immunoassays in 110 and 106 respective samplings compared to LC\u2010MS\/MS in all. Ratios of aldosterone\u2010to\u2010cortisol below 1.0 in adrenal versus peripheral vein samples defined relative aldosterone suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among all AVS procedures, 9.7% (21\/216) of samplings with immunoassay measurements showed ABAS, threefold more (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004) than the 3.2% (7\/216) with LC\u2010MS\/MS. Rates of ABAS were particularly high with the Liaison immunoassay compared to LC\u2010MS\/MS (14.5% vs. 0.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and remained higher after substitution of immunoassay\u2010measured with LC\u2010MS\/MS\u2010measured cortisol (10.9% vs. 0.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0007). Among 106 procedures involving iSYS immunoassay measurements, rates of ABAS at 4.7% were a third (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0202) those of the Liaison immunoassay and did not differ from LC\u2010MS\/MS measurements (5.7%). ABAS confined to LC\u2010MS\/MS measurements in one patient was resolved by a second sampling that revealed pronounced aldosterone secretion versus earlier suppression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ABAS is a relatively common artefact of the Liaison immunoassay of aldosterone. More rarely, ABAS may reflect sampling blood from an adrenal venous tributary that does not drain from the site of excess aldosterone secretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70135","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:40:20Z","timestamp":1774845620000},"page":"175-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry"],"prefix":"10.1111","volume":"105","author":[{"given":"Christina","family":"Pamporaki","sequence":"first","affiliation":[{"name":"Department of Medicine III University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina T.","family":"Fuss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes University Hospital, University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Kickuth","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital, University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"K\u00fcrzinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes University Hospital, University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Peitzsch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine Medical Faculty and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8560-9920","authenticated-orcid":false,"given":"Sybille","family":"Fuld","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department Information Services and High Performance Computing, Center for Interdisciplinary Digital Sciences Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-4976","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research Monash University Victoria Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Department of Medicine IV University Hospital, Ludwig Maximilian University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0601-4334","authenticated-orcid":false,"given":"Sven","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition University Hospital Zurich and the LOOP Zurich Medical Research Center Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Department of Medicine IV University Hospital, Ludwig Maximilian University Munich Munich Germany"},{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition University Hospital Zurich and the LOOP Zurich Medical Research Center Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques W. 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