{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:11:38Z","timestamp":1788790298532,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to assess the efficacy and safety of ultrasound\u2010guided radiofrequency ablation (RFA) in elderly patients with primary hyperparathyroidism (PHPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients aged \u2265\u200960 years with PHPT who underwent ultrasound\u2010guided RFA at a single center between May 2021 and May 2025. A total of 36 patients were analyzed. Laboratory parameters, including serum calcium and intact parathyroid hormone (iPTH), were assessed before and after the procedure. All patients were followed for at least 6 months. Cure was defined as normalization of both serum calcium and iPTH levels during follow\u2010up. Procedural outcomes, complications, and factors associated with treatment response were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of the cohort was 70.4 (\u00b18.69) years. After a single RFA session, 28 of 36 patients achieved a cure. When repeat procedures were included, the overall cure rate increased to 83.3% (30\/36). The key procedure\u2010related adverse events were postoperative mild pain and hoarseness. Hoarseness was transient in most cases; permanent hoarseness occurred in one patient. No major life\u2010threatening complications were observed. Baseline characteristics did not differ significantly between cured and non\u2010cured patients. Patients who developed hoarseness were older and had lower baseline magnesium levels than those without hoarseness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultrasound\u2010guided RFA appears to be an effective and safe minimally invasive treatment option for selected elderly patients with PHPT, achieving acceptable cure rates with a favorable safety profile. RFA may represent a valuable alternative for elderly or frail patients who are at increased surgical risk. Prospective studies with larger cohorts and longer follow\u2010up are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70138","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:45:00Z","timestamp":1775187900000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Guided Radiofrequency Ablation for the Treatment of Primary Hyperparathyroidism in Elderly Patients"],"prefix":"10.1111","volume":"105","author":[{"given":"Samet","family":"Alkan","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Manisa Celal Bayar University Faculty of Medicine Manisa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat Can","family":"Guney","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Manisa Celal 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The Forgotten Electrolyte\u2010A Review on Hypomagnesemia","volume":"7","author":"Ahmed F.","year":"2019","journal-title":"Medical Sciences (Basel, Switzerland)"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad718"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.03.014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3514-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2023.02.020"}],"container-title":["Clinical 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