{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:17:31Z","timestamp":1788268651023,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The effect of transsphenoidal surgery (TSS) on the hypothalamic\u2010pituitary\u2010gonadal (HPG) axis in patients with non\u2010functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that predict its recovery after TSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>One hundred twenty\u2010two consecutive patients, 73 men and 49 women, with NFPA planned for TSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Endocrine function and QoL were assessed before and 12 months after TSS. Psychological well\u2010being was evaluated using the Psychological General Well\u2010Being index (PGWBi).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before surgery, 50 of 73 (68%) men had hypogonadotropic hypogonadism (HH), of whom four (8%) recovered. Eight of 13 (62%) women of reproductive age had preoperative HH, of whom 5 (63%) regained regular menstrual cycles. Preoperative central hypothyroidism (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) and male sex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) were predictors of persistent HH.\n                    <\/jats:p>\n                    <jats:p>\n                      The median total PGWBi score increased in both men and women following surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Comparing psychological well\u2010being within subgroups in patients with preoperative HH, categorised by sex (men or women of reproductive age) and postoperative recovery status, only women of reproductive age who recovered their HPG axis experienced improved psychological well\u2010being.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HH is frequent in men and women with NFPA planned for TSS. Postoperative HPG axis recovery rate is higher in women and is associated with improved QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70139","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:25:31Z","timestamp":1775471131000},"page":"442-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non\u2010Functioning Pituitary Adenoma"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6109-9678","authenticated-orcid":false,"given":"Victor","family":"Hantelius","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Medicine Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Endocrinology, Sahlgrenska University Hospital ENDO\u2010ERN (European Reference Network on Rare Endocrine Conditions) and University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudmundur","family":"Johannsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Medicine Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Endocrinology, Sahlgrenska University Hospital ENDO\u2010ERN (European Reference Network on Rare Endocrine Conditions) and University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Jakobsson","sequence":"additional","affiliation":[{"name":"University of Gothenburg Centre for Person\u2010Centred Care (GPCC) Gothenburg Sweden"},{"name":"Institute of Health and Care Sciences, The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Thurin","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Radiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hallen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurosurgery Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skoglund","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurosurgery Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Ragnarsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Medicine Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Endocrinology, Sahlgrenska University Hospital ENDO\u2010ERN (European Reference Network on Rare Endocrine Conditions) and University of Gothenburg Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg Gothenburg 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