{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:34Z","timestamp":1785776254286,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A retrospective cross\u2010sectional analysis with an ethnicity\u2010matched control cohort examining the relationship between free thyroxine (FT4), thyroid\u2010stimulating hormone receptor antibody (TRAb) and absolute neutrophil count (ANC) in newly diagnosed hyperthyroidism, and assessing the influence of ethnicity on ANC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with newly diagnosed hyperthyroidism between August 2020 to July 2025 and concurrently available FT4, TRAb and ANC were included. Graves' disease (GD) was defined by Roche Elecsys TRAb \u2265\u20091.75 IU\/L. An ANCOVA tested main effects of TRAb and FT4 on ANC and their interaction. ANC was compared between GD and non\u2010GD hyperthyroidism and with euthyroid controls, stratified by Asian, Black and White ethnicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 237 individuals (152 GD, 85 non\u2010GD), median [Q1\u2013Q3] ANC was lower in GD (3.44 [2.67\u20134.64]\u2009\u00d7\u200910\u2079\/L) than non\u2010GD (3.71 [2.92\u20135.12]\u2009\u00d7\u200910\u2079\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), and 9.9% and 3.5%, respectively, had low ANC\u2009&lt;\u20092.0\u2009\u00d7\u200910\u2079\/L. There was a significant TRAb and FT4 interaction for ANC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with higher FT4 associated with lower ANC in patients with high TRAb, but not in TRAb\u2010negative patients. In hyperthyroidism and controls, Black ethnicities had lower ANC and higher prevalence of low ANC compared to Asian or White ethnicities. In GD with a low ANC at diagnosis, ANC increased on average 1.14\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      (95% CI 0.50\u20131.77\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) upon achieving euthyroidism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Graves' hyperthyroidism is associated with ANC decrease that is greatest when substantially high TRAb and FT4 coexist. ANC is further influenced by ethnicity. Mild neutropenia, particularly in ethnicities predisposed to benign ethnic neutropenia, should not delay antithyroid treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70151","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:32:55Z","timestamp":1777523575000},"page":"339-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethnicity, TSH\u2010Receptor Antibody (TRAb) and Thyrotoxicosis Severity Are Determinants of Neutrophil Count in Newly Diagnosed Hyperthyroidism"],"prefix":"10.1111","volume":"105","author":[{"given":"Aman Kaur","family":"More","sequence":"first","affiliation":[{"name":"Endocrinology and Diabetes The Royal Wolverhampton NHS Trust Wolverhampton UK"},{"name":"Clinical Biochemistry, Black Country Pathology Services The Royal Wolverhampton Trust Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokaiba","family":"Afrin","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Black Country Pathology Services The Royal Wolverhampton Trust Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Black Country Pathology Services The Royal Wolverhampton Trust Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Ford","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Black Country Pathology Services The Royal Wolverhampton Trust Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harit","family":"Buch","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes The Royal Wolverhampton NHS Trust Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejas","family":"Kalaria","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Black Country Pathology Services The Royal Wolverhampton Trust Wolverhampton UK"},{"name":"School of Medicine and Clinical Practice University of Wolverhampton Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/CEN.14313"},{"key":"e_1_2_10_3_1","unstructured":"National Institute for Health and Care Excellence (NICE). Thyroid Disease: Assessment and Management. NICE Guideline NG145. Published November 20 2019. Last updated October 12 2023 https:\/\/www.nice.org.uk\/guidance\/ng145."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/THY.2016.0229"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.21014"},{"key":"e_1_2_10_6_1","first-page":"519","article-title":"Ein Fall Von Malignem Morbus Basedowii Kombiniert Mit Den Symptomen der Pseudoleukamie","volume":"54","author":"Caro L.","year":"1907","journal-title":"Berliner Klinische Wochenschrift"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40618-024-02355-W"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BCMD.2019.01.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BLRE.2019.06.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/CEN.13133"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM-2023-0026"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/DIAGNOSTICS13162707"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000886"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2478\/jomb-2019-0004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111663"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365-2265.2004.02029.X"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612013397898"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0875"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7727\/WIMJ.2013.113"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.13345"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1000360"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-7-200704030-00004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/ATM-22-719"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/07435800.2025.2505627"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:33:23Z","timestamp":1785774803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/cen.70151"],"URL":"https:\/\/doi.org\/10.1111\/cen.70151","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}