{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:16Z","timestamp":1791363316124,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Hypocalcemia is the most common complication following thyroidectomy. Previous studies yielded inconsistent results on whether vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      prevents postoperative hypocalcemia and were conducted in non\u2010European countries with different dietary habits and baseline vitamin D levels. Therefore, we explored the effect of preoperative vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      on post\u2010thyroidectomy hypocalcemia in a Dutch cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients undergoing thyroidectomy between 2023 and 2025 received 100,000\u2009IU vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      1 week before surgery (\u201cvitamin D group\u201d) and were compared to a historical cohort (2019\u20132022) without vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      supplementation (\u201ccontrol group\u201d). Outcomes included incidence of hypocalcemia (albumin\u2010adjusted calcium &lt;\u20092.00\u2009mmol\/L), need for postoperative supplementation, time until normocalcemia, length of hospital stay, and readmissions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty patients received preoperative vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      and were compared to 154 controls (82.8% female, median age: 55 years [IQR: 43\u201366]). Vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      supplementation was associated with a reduced risk of biochemical hypocalcemia at all postoperative time points (OR 0.28, 95% CI: 0.11\u20130.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), corresponding to a number needed to treat of five patients to prevent one case of hypocalcemia. As compared to controls, the need for postoperative supplementation and time to recover from hypocalcemia were lower in the vitamin D group (32.0% vs. 53.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007; and 0 [0\u20132] vs. 3 [0\u201311] days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002, respectively). No differences were observed in length of hospital stay or readmissions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although larger randomized trials are needed to confirm these observations, preoperative vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      was associated with a significant reduction in post\u2010thyroidectomy hypocalcemia in this observational cohort study. Given its low costs, this intervention may be considered for routine implementation in thyroidectomy patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70152","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:46:26Z","timestamp":1777538786000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D Supplementation to Prevent Post\u2010Thyroidectomy Hypocalcemia"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-3177","authenticated-orcid":false,"given":"Jeresa I. A.","family":"Willems","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-8030","authenticated-orcid":false,"given":"Daan J. L.","family":"van Twist","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy M.","family":"Pickwell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L. H.","family":"van Battum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutgert","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"van Bastelaar","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Medici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Academic Center for Thyroid Diseases, Erasmus Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Academic Center for Thyroid Diseases, Erasmus Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick F.A.","family":"Tummers\u2010de Lind van Wijngaarden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Zuyd Thyroid Center, Zuyderland Medical Center Sittard\/Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-01075-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0309"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10002-1421"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13897"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.04.036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121001523"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07791-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28174"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956504"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2020-001644"},{"key":"e_1_2_9_13_1","unstructured":"C.Lai Z.Wz I.Ah et al.Randomized Control Study Using Vitamin D in Preventing Post Total Thyroidectomy Transient Hypocalcemia."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.195997"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.967451"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.4796"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.05.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26775"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4579"},{"key":"e_1_2_9_20_1","unstructured":"T. M. E.Shahidy M. A.Yassin andF.FayekSingle\u2010Dose Preoperative Vitamin D and Calcium Supplementation to Prevent Hypocalcemia After Total Thyroidectomy: A Comparative Clinical Trial."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.08.035"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6683089"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5893.643"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6074.1473"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31860"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525626"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2021.01.016"},{"key":"e_1_2_9_29_1","unstructured":"A.Habib D. K.Rohra S. A.Saghir S. K.Udani andR.WoodResponse of a Single \u201cMega Intramuscular Dose\u201d of Vitamin D on Serum 25OHD and Parathyroid Hormone Levels.2012;22."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802419081"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0502"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:43:15Z","timestamp":1791362595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/cen.70152"],"URL":"https:\/\/doi.org\/10.1111\/cen.70152","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}