{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:17:31Z","timestamp":1788268651051,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the accuracy of expert\u2010performed ultrasonography (US) for preoperative localization in minimally invasive parathyroidectomy (MIP) compared with community US and other imaging modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral center for endocrine surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, single\u2010center diagnostic accuracy study of 227 patients with primary hyperparathyroidism who underwent surgery and pre\u2010operative imaging by a dedicated neck radiologist (expert US). Sensitivity, specificity, and positive predictive value (PPV) were calculated, and were compared to other imaging modalities including community US, 99mTc\u2010MIBI, SPECT\u2010CT and 4DCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Expert US showed high sensitivity (89%), specificity (98%), and PPV (95%), correctly localizing adenomas in 89% of cases. It outperformed the sensitivity and specificity of community US (50%\/95%), MIBI (75%\/95%), SPECT\u2010CT (82%\/96%) and 4D\u2010CT (52%\/94%), respectively, particularly in atypical cases like ectopic adenomas (25% prevalence) and multiglandular disease (6% prevalence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Expert\u2010performed US should be considered the primary imaging modality for guiding MIP. Surgeons should consider referring patients to an expert ultrasonographer in cases of suspected ectopic adenoma, presence of multiglandular disease, before referring to 4D\u2010CT scans or when considering bilateral neck explorations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70154","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:40:12Z","timestamp":1778125212000},"page":"386-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Parathyroid Localization in Real Life: The Role of Expert\u2010Performed Ultrasonography"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6252-3646","authenticated-orcid":false,"given":"Tzahi","family":"Yamin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Samson Assuta University Hospital Ashdod Israel"},{"name":"Faculty of Medicine Ben Gurion University of the Negev Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Battat","sequence":"additional","affiliation":[{"name":"A.R.M. Center for Head and Neck Surgery and Oncology Assuta Hospital Ramat Hachayal  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annat","family":"Blank","sequence":"additional","affiliation":[{"name":"A.R.M. Center for Head and Neck Surgery and Oncology Assuta Hospital Ramat Hachayal  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Meirsdorf","sequence":"additional","affiliation":[{"name":"A.R.M. 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