{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:24Z","timestamp":1785776244991,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and evaluate a simplified method for skeletal age assessment in adolescents as a rapid alternative to the Greulich\u2013Pyle (GP) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective methodological study comparing the simplified method with the GP atlas, with duplicate readings by experienced and inexperienced raters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>One hundred and seventeen hand and wrist radiographs (67 boys, 50 girls) from adolescents referred for short stature but otherwise healthy. Radiographs with GP\u2010assessed bone age \u2265\u20099 years in girls and \u2265\u200911 years in boys were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Bone age was scored independently using GP and simplified methods in two rounds by two paediatric endocrinologists and, for the simplified method, two residents. Outcomes included measures of agreement between methods, the proportion of readings within \u00b11 year of GP, and inter\u2010 and intra\u2010rater reliability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among experienced raters, the simplified method showed minimal bias relative to GP, with about 91% of readings within \u00b11 year. Reliability coefficients for both methods exceeded 0.9. Repeatability of the simplified method was slightly lower than GP but remained within clinically acceptable limits and close to predefined acceptability thresholds for inexperienced raters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The simplified method offers a transparent, standardised, and reproducible approach to adolescent skeletal age assessment. Although not intended to replace the GP method, it is particularly suited to research involving large datasets or resource\u2010limited environments and to population\u2010level skeletal analyses. In busy clinics, it may also serve as a quick check of radiologists' GP\u2010based interpretations, allowing review of reported bone ages without repeating a full atlas assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70160","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:09:43Z","timestamp":1778839783000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Simplified Method for Assessing Bone Age in Adolescents"],"prefix":"10.1111","volume":"105","author":[{"given":"Yehuda","family":"Limony","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology &amp; Diabetes Unit, Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-2603","authenticated-orcid":false,"given":"Alon","family":"Haim","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology &amp; Diabetes Unit, Soroka University Medical Center Beer\u2010Sheva Israel"},{"name":"Department of Public Health Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friger","sequence":"additional","affiliation":[{"name":"Department of Public Health Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Alamour","sequence":"additional","affiliation":[{"name":"Pediatric D Department Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Kristal","sequence":"additional","affiliation":[{"name":"Pediatric D Department Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Hershkovitz","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology &amp; Diabetes Unit, Soroka University Medical Center Beer\u2010Sheva Israel"},{"name":"Department of Public Health Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"},{"name":"Pediatric D Department Soroka University Medical Center Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.2.172"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2020.2020.0091"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-67-801-848"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.108.3.511"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_315_18"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358009004719"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.72.857.10505010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.118.2.320"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0307305"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.580314"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000001248"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-03684-9"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.70160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.70160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:33:22Z","timestamp":1785774802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.70160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/cen.70160"],"URL":"https:\/\/doi.org\/10.1111\/cen.70160","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}