{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:23:19Z","timestamp":1788211399090,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Subacute thyroiditis (SAT) is a differential diagnosis in the clinical care of hypo\u2010 and hyperthyroid patients, but large\u2010scale population data on the incidence, patient characteristics, and outcome are limited. Thus, the aim was to determine the incidence of SAT in the Danish population and to characterise patient demographics and the risk of permanent hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study based on Danish nationwide health registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Individuals diagnosed with SAT at Danish hospitals from 1995 to 2016, covering the years before and after the implementation of mandatory iodine fortification in Denmark as of July 2000.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Annual incidence rates of SAT were calculated overall and by geographical region (East and West Denmark). The development of permanent hypothyroidism following SAT was evaluated based on redeemed prescriptions of levothyroxine (L\u2010T4) within a 4\u2010year follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1763 individuals were identified with a diagnosis of SAT among 1,747,168 individuals at risk. The overall nationwide incidence increased from 3.3\/100,000 individuals (95% confidence interval (CI): 2.5\u20134.4) in 1995 to 6.2\/100,000 individuals (95% CI: 5.1\u20137.6) in 2016, with no regional difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.18). Follow\u2010up showed that 459 of 1763 patients with SAT (26.0%) started treatment with L\u2010T4, and in 224 of these patients (48.7%), the duration of L\u2010T4 treatment exceeded 36 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a Danish nationwide cohort, the incidence of SAT increased during a 22\u2010year period without geographical difference. Notably, the frequency of long\u2010term L\u2010T4 treatment was high, emphasising a focus on the post\u2010diagnosis management of patients with SAT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70173","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:45:16Z","timestamp":1781754316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4293-8578","authenticated-orcid":false,"given":"Marco Juul","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Henrik","family":"Bruun","sequence":"additional","affiliation":[{"name":"Research Data and Biostatistics Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna Maria Uldall","family":"Torp","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Department of Geriatrics Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine Linding","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1461444810365020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-021-09648-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202403264R"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021799"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347442"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00047"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0212"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19159388"},{"issue":"11","key":"e_1_2_9_10_1","first-page":"1","article-title":"Characteristics of Patients with Subacute Thyroiditis","volume":"70","author":"Kjellerup C. 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