{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:05Z","timestamp":1785732365883,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the impact of pathogenic genetic variants on growth outcomes following 3 years of recombinant human growth hormone (rhGH) therapy in children born small for gestational age with persistent short stature (SGA\u2010SS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      One hundred and seventy\u2010nine SGA\u2010SS children who underwent clinical and genetic evaluation were classified into variant\u2010positive (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) and variant\u2010negative groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009149).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Clinical characteristics and growth outcomes were assessed over 3 years of rhGH therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, the variant\u2010positive group had significantly lower height standard deviation score (SDS) (\u22122.83 vs. \u22122.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher rates of intellectual disability (36.7% vs. 7.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and congenital anomalies (30.0% vs. 6.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). rhGH therapy promoted longitudinal growth in both groups (evaluated\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009142); after 3 years, the estimated marginal mean (EMM) of height SDS reached \u22121.30\u2009\u00b1\u20090.10 in the variant\u2010positive group and \u22120.93\u2009\u00b1\u20090.04 in the variant\u2010negative group. However, linear mixed model analysis revealed a progressive attenuation of incremental height SDS gain in the variant\u2010positive group as the treatment progressed, with significant interaction estimates observed at Year 1 (Estimate \u22120.18), Year 2 (Estimate \u22120.31) and Year 3 (Estimate \u22120.36; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As one of the first longitudinal analyses utilizing repeated\u2010measures modelling in a genetically characterized patient population, this study demonstrates that while rhGH therapy effectively promoted linear growth in SGA\u2010SS children, patients with a molecular diagnosis presented with lower baseline stature and an attenuated incremental growth response over time, highlighting the importance of genetic evaluation for personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.70186","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:21:23Z","timestamp":1785730883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Recombinant Human Growth Hormone Therapy in Small\u2010for\u2010Gestational\u2010Age Children With Short Stature: A Stratified Analysis Based on Genetic Variant Status"],"prefix":"10.1111","author":[{"given":"Sanghee","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hallym University Kangnam Sacred Heart Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Sacred Heart Hospital Anyang Republic of 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Byul","family":"Kwon","sequence":"additional","affiliation":[{"name":"The Key Growth Clinic Seongnam Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Kangnam Sacred Heart Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Jun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Chuncheon Sacred Heart Hospital Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Suk","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ajou University Hospital, Ajou University School of Medicine Suwon Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inha University Hospital, Inha University College of Medicine Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inha University Hospital, Inha University College of Medicine Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Hallym Institute of Translational Genomics and Bioinformatics Hallym University Medical Center Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangkyoon","family":"Hong","sequence":"additional","affiliation":[{"name":"Hallym Institute of Translational Genomics and Bioinformatics Hallym University Medical Center Anyang Republic of 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